Meta-pyrazolylaminotetramisole analogs and their use in pharmace

Details Meta-pyrazolylaminotetramisole analogs and their use in pharmace Meta-pyrazolylaminotetramisole analogs and their use in pharmace

1981-05-15

1983-06-21

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548154, 548195, A61K 31425, C07D51304

Patent

active

043894062

ABSTRACT:
Compounds of formula (I) in the 1-form ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from hydrogen, optionally substituted (C.sub.1-7) alkyl, optionally substituted aryl and aromatic heterocyclyl and the dotted line is an optional direct bond, and acid addition salts thereof, are useful in treating worm infections in mammals. Compounds (I) are produced by forming the amide of m-aminotetramisole or by closing the dihydroimidazoline ring.

REFERENCES:
patent: 3673205 (1972-06-01), Spicer
patent: 4137321 (1979-01-01), Leeming et al.
patent: 4143147 (1979-03-01), Leeming et al.

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