Mesoporous glass as nucleant for macromolecule crystallisation

Single-crystal – oriented-crystal – and epitaxy growth processes; – Processes of growth from liquid or supercritical state – Having growth from a solution comprising a solvent which is...

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C156S089110, C423S173000, C423S180000, C501S002000, C501S039000, C501S054000, C501S063000, C623S023620

Reexamination Certificate

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10534088

ABSTRACT:
A method of facilitating the crystallisation of a macromolecule comprising the step of adding a mesoporous glass to a crystallisation sample wherein the mesoporous glass comprises pores having diameters between 4 nm and 100 nm and has a surface area of at least 50 m2/g. A method of facilitating the crystallisation of a macromolecule comprising the step of adding to a crystallisation sample a mesoporous glass of the composition Si02; CaO—P205-SiO2or Na20-CaO—P205-SiO2, wherein each of the Ca, P, Si or Na atoms within the compositions may be substituted with a suitable atom chosen from B, Al, Ti, Mg, or K, and, optionally, the composition may also include heavy elements to enhance X-ray diffraction contrast such as Ag, Au, Cr, Co, Sr, Ba, Pt, Ta or other atom with an atomic number over 20.

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