Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-29
1995-03-14
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514410, 540145, A61K 31555, A61K 3140
Patent
active
053977777
ABSTRACT:
A chelated compound of the formula: ##STR1## where R.sub.1 is independently at each occurrence, R.sub.2, ##STR2## R2 is independently at each occurrence hydrogen, lower alkyl, lower alkyl ester, lower alkyl ether, hydroxy or halogen; A is H, Li, Na, Ca+, Mg+ or Zn+; and Mn is trivalent manganese; provided that, at least two and no more than three R.sub.1 radicals are ##STR3## The compound of the invention is particularly suitable for use in a physiologically compatible composition comprising a physiologically compatible liquid carrier for magnetic resonance imaging. The compound is also suitable as a chelate for removal of manganese from a system.
The invention also comprises a method for enhanced magnetic imaging of a mammal organism which comprises introducing the composition at a level of from 20 to 200 mg/Kg of body weight into the circulatory system of the organism; and making a magnetic resonance image of at least a portion of said organism at from 30 minutes to 36 hours after said introduction.
REFERENCES:
patent: 5169944 (1992-12-01), Nelson et al.
patent: 5236915 (1993-08-01), Fiel
Place et al., "MRI Contrast-Dose Relationship of Manganese (III) Tetra (4-Sulfonatophenyl) Porphyrin with Human Xenograft Tumors in Nude Mice at 2.0 T," Magnetic Resonance Imaging, vol. 10, pp. 919-928, 1992.
Place, et al. Proc. of the 9th Annual Meeting of the Soc. of Mag. Res., N.Y., 1990: 733.
I. Okura et al., Chemical Abstracts, vol. 97, 1982, Abstract #41391z.
Bloom Mark G.
Dunn Michael L.
Health Research , Inc.
Shah Mukund J.
Sripada Pavanaram K.
LandOfFree
Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing ag does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing ag, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing ag will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-713853