Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1991-08-23
1993-04-13
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530397, 530399, 530380, 435 71, 435 79, 514402, 514635, C07K 300, C12Q 100, A01N 3752, A61K 31155
Patent
active
052024245
ABSTRACT:
The present invention relates to a method and associated agents for measuring the presence and amount of advanced glycosylation endproducts in cells and fluids. The methods take advantage of the existence of receptors and receptor complexes for AGEs and include receptor-containing ligands comprising whole mesangial and other cells, mesangial cellular fragments and protein extracts therefrom. Competitive assays, sandwich assays and assays involving AGE antisera are disclosed. Numerous diagnostic applications are defined and test kits are also contemplated.
REFERENCES:
Skolnik, E. et al., J. Exp. Med 174:931/939 (Oct., 1991).
Vlassara, H. et al., Science (Washington, D.C. 240:1546).
Esposito, C. et al., J. Exp. Med 170:1387 (1989).
Schlondorf, D. J. Fed. AM. Soc. Exp. Biol. 1:272 (1987).
Lovett, D. H. et al., Kidney Int. 30/246 (1986).
Cerami Anthony
Vlassara Helen
Lacey David L.
The Rockefeller University
Wang Gian P.
LandOfFree
Mesangial cell-derived receptors for advanced glycosylation endp does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mesangial cell-derived receptors for advanced glycosylation endp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mesangial cell-derived receptors for advanced glycosylation endp will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1156294