Merozoite surface glycoproteins

Details Merozoite surface glycoproteins Merozoite surface glycoproteins

1989-05-30

1991-04-16

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530808, 530809, C12N 500, A61K 3514, C07K 300, C07K 1300

Patent

active

050081985

ABSTRACT:
The invention comprises antigenic glycoproteins substantially similar to antigenic glycoproteins present on the surface of the merozoite form of Plasmodium falciparum, including glycoproteins of molecular weights of about 56,000 present in the Geneva and FVO isolates and about 50,000 that is present in the Honduras I/CDC, Indochina 1, Kenya and Tanzania I isolates. The invention also comprises monoclonal antibodies 4-8-5D (HB 8938) which bind to the 56,000 glycoprotein of the invention, a hybridoma cell line that is capable of producing these monoclonal antibodies, and vaccines and vaccine compositions comprising these glycoproteins or epitopes substantially similar to or cross reactive with these glycoproteins or genes or gene fragments encoding such epitopes.

REFERENCES:
patent: 4835259 (1989-05-01), Reese et al.
Clark, J. T. et al., Mol. and Biochem. Parasitol, 32:15-24, 1989, "46-53 KDa Glycoprotein . . . ".
Stanley, H. A. et al., PNAS (U.S.A.) 83:6093-6097, "Plasmodium Falciparu Polypeptides . . . ".
Smythe, J. A. et al., PNAS (U.S.A.):85, pp. 5195-5199, Jul. 1988, "Indentification of Two Integral . . . ".
Epping et al., Mol. Biochem. Parasitol., 28:1-10 (1988).
Pirson et al., J. Immunol., 134:1946-1951 (1985).
Perrin et al., Immunological Rev., 61:245-269 (1982).
Reese et al., Am. J. Trop. Med. Hyg., 30:1168-1178 (1981).
Perrin et al., Transactions of the Royal Society of Tropical Medicine and Hygiene, 75:163-165 (1981).
Brown et al., Nature, 297:591-593 (1982).
Myler et al., Molecular and Biochemical Parasitology, 9:37-45 (1983).
Heidrich et al., Z. Parasitenkd, 69:715-725 (1983).
Freeman et al., J. Exp. Med., 158:1647-1653 (1983).
Holder et al., J. Exp. Med., 156:1528-1538 (1982).
Hall et al., Molecular and Biochemical Parasitology, 7:247-265 (1983).
Howard et al., Molecular and Biochemical Parasitology, 10:319-334 (1984).
Howard et al., Malaria and the Red Cell, John Eaton, ed., pp. 45-61 (1984).
Dubois et al., Proc. Natl. Acad. Sci. U.S.A., 81:229-232 (1984).
Holder et al., J. Exp. Med., 160:624-629 (1984).
Perkins, Molecular Biochemical Parasitology, 5:55-64 (1982).
Kilejian, Proc. Natl. Acad. Sci. U.S.A., 77:3695-3699 (1980).
Miller et al., Journal of Immunology, 114:1237-1242 (1975).

Affiliated with

Also associated with

Rating

Merozoite surface glycoproteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Merozoite surface glycoproteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Merozoite surface glycoproteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-420918