Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-10-04
1997-07-08
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241911, 4241921, 435 693, 536 235, C07K 1444, C12N 1530, A61K 39005, A61K 3900
Patent
active
056462476
ABSTRACT:
Disclosed are compounds comprising an amino acid sequence selected from the group consisting of malarial merozoite proteins located at the apical end of merozoites and peptides the peptides comprising synthetic versions, derivatives, analogs and fragments of the merozoite proteins. Certain of these compounds have the property of binding to a Duffy blood group antigen from primate red blood cells. Disclosed are also nucleic acids comprising a nucleotide sequence encoding such peptides or proteins and nucleic acids hybridizing therewith. The compounds and antibodies recognizing these compounds are useful in inhibiting invasion of susceptible primate red blood cells by malarial merozoites.
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Barnwell John W.
Galinski Mary R.
Moore William W.
New York University
Wax Robert A.
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