Merosin, nucleic acids encoding, fragments and uses thereof

Details Merosin, nucleic acids encoding, fragments and uses thereof Merosin, nucleic acids encoding, fragments and uses thereof

1993-07-08

1995-08-22

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530413, 530417, A61K 3814, A61K 3816, C07K 1478

Patent

active

054441587

ABSTRACT:
A substantially pure heterotrimeric laminin variant comprising the structure M-X-B2, wherein M is the M polypeptide of merosin; X is selected from the group consisting of the B1 chain of laminin and S-laminin; and B2 is the B2 chain of laminin.

REFERENCES:
Deutzmann et al, Eur. J. Biochem. 177 (1988), pp. 34-45.
Leivo, I. et al "Merosin, a protein specific for basement membranes of Schwann cells in development", Proc. Natl Acad Sci USA, 85:1544-48 (1988).
Engvall et al, "Merosin promotes cell attachment in RN22 Schwann cells," E. Cell Res., 198:115-123 (1992).
Ohno et al., Isolation of Laminin from Human Placental Basement Membranes: Amnion, Chorion and Chorionic Microvessels, Biochem. and Biophys. Res. Comm. 112:1091-1098 (1983).
George R. Martin and Rupert Timpl, Laminin and Other Basement Membrane Components, Ann. Rev. Cell Biol. 3:57-85 (1987).
Dale E. Hunter et al., A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction, Nature 338:229-233 (1989).
Arthur D. Lander et al., Laminin is associated with the "neurite outgrowth-promoting factors" found in conditioned media, Proc. Natl. Acad. Sci. USA 82:2183-2187 (1985).
George E. Davis et al., Isolation and Characterization of Rat Schwannoma Neurite-promoting Factor: Evidence that the Factor Contains Laminin.sup.1, The Journal of Neuroscience 5:2662-2671 (1985).
J. G. Steele and H. Hoffman, Neurite-Promoting Activity From Fetal Skeletal Muscle: Partial Purification of a High-Molecular-Weight Form, Journal of Neuroscience Research 15:323-339 (1986).
Alfred W. Sandrock, Jr. and William D. Matthew, Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay, Proc. Natl. Acad. Sci. USA 84:6934-6938 (1987).
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Cornbrooks et al., "In vivo and in vitro observations on laminin production by Schwann cells", Proc. Natl. Acad. Sci. USA vol. 80:3850-3854 (1983).
Engvall et al., "Merosin is a tissue-restricted basement membrane component and a member of a family of laminin like protein", J. Cell Biol., 109 4 part 2, 1989 (New York US), Twenty-Ninth Annual Meeting of the American Society for Cell Biology, Houston, Texas, 5-9 Nov. 1989, Minisymposium 1, Abstract 3.
Ehrig et al., "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein", Proc. Natl. Acad. Sci. USA vol. 87:3264-3268 (1990).
Hagg et al., "Merosin is associated with neurons of the adult mammalian central nervous system", J. Cell. Biol., 111, 5 part 2, (New York, US), Abstract 2227 (1990).
Engvall et al., "Distribution of four laminin variants: tissues restricted distribution of heterotrimers assembled from five different subunits", Chemical Abstracts vol. 114, No. 9 Abstract 79032r (1991), & Cell Regul. 1(10):731-40 (1990).
Martin, G. R., et al., "Laminin and Other Basement Membrane Components", Ann. Rev. Cell Biol. 3:57-85 (1987).
Lander, A. D., et al., "Laminin is Associated with the `Neurite Outgrowth-promoting Factors` Found in Conditioned Media", Proc. Natl. Acad. Sci. USA 82:2183-87 (1985).
Davis, G. E., et al., "Isolation and Characterization of Rat Schwannoma Neurite-promoting Factor: Evidence that the Factor Contains Laminin", J. Neurosci. 5:2662-71 (1985).
Steele, J. G., et al., "Neurite-Promoting Activity From Fetal Skeletal Muscle: Partial Purification of a High-Molecular-Weight Form", J. Neurosci. Res. 15:323-39 (1986).
Sandrock, A. W., et al. "Identification of a Peripheral Nerve Neurite Growth-promoting Activity by Development and Use of an In Vitro Bioassay", Proc. Natl. Acad. Sci. USA 84:6934-38 (1987).
Hassell, J. R., et al., "Isolation of Two Forms of Basement Membrane Proteoglycans", J. Biol. Chem. 260:8098-8105 (1984).
Ohno, M., et al. "Isolation of Laminin From Human Placental Membranes: Amnion, Chorion, and Chorionic Microvessels", Chemical Abstracts, vol. 98, No. 25, Jun. 20, 1983, p. 365, abstract 213310m.

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