Mercaptosulfide metalloproteinase inhibitors

Details Mercaptosulfide metalloproteinase inhibitors Mercaptosulfide metalloproteinase inhibitors

1993-10-06

1995-10-03

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514399, 514419, 514601, 514602, 514604, 514616, 514618, 5483401, 548485, 548494, 548495, 564 80, 564 81, 564 85, 564153, 564154, A61K 3140, A61K 31165, C07D20932, C07C23305

Patent

active

054552621

ABSTRACT:
Novel mercaptosulfide matrix metalloproteinase inhibitors of the Formula I, ##STR1## wherein: n is 0 or 1;

REFERENCES:
patent: 4513009 (1985-04-01), Roques et al.
patent: 5145872 (1992-09-01), Chiarino et al.
Schwartz et. al., Matrix Supplement No. 1, pp. 309-310, 1992.
M. Brannstrom, et al., "Inhibitors of Mammalian Tissue Collagenase and Metalloproteinases Suppress Ovulation in the Perfused Rat Ovary", Endicrinology 122:1715-1721 (1988).
C. Librach, et al., "92-kD Type IV Collagenase Mediates Invasion of Human Cytotrophoblasts", J. Cell Biol. 113:437-449 (1991).
M. A. Schwartz, et al., "Synthetic Inhibibors of Bacterial and Mammalian Interstitial Collagenases", Prog. Medicinal Chem. 29:271-334 (1992).
L. M. Matrisian, "The Matrix-Degrading Metalloproteinases", Bioessays 14: 455-463 (1992).
H. Birkedal-Hansen, et al., "Matrix Metalloproteinases: A Review", Crit Revs. Oral Biol. Med. 4(2): 197-250 (1993).
J. M. Delaisse, et al., "The Effects of Inhibitors of Cysteine-Proteinases and Collagenase on the Resorptive Activity of Isolated Osteoclasts", Bone 8: 305-313 (1987).
J. M. Delaisse, et al., "A New Synthetic Inhibitor of Mammalian Tissue Collagenase Inhibits Bone Resorption in Culture", Biochem. Biophys. Res. Communs. 133: 483-490 (1985).
M. A. Moses, et al., "Inhibitors of Angiogenesis (Review)", Biotechnology 9: 630-634 (1991).
R. Langer, et al., "Control of tumor growth in animals by infusion of an angiogenesis inhibitor", Proc. Natl. Acad. Sci. USA 77: 4331-4335 (1980).
J. White, "Minocycline for Dystrophic Epidermolysis Bullosa", Lancet I: 966 (1988).
P. Humbert, et al., "Tetracyclines for Dystrophic Epidermolysis Bullosa", Lancet II: 277 (1989).
F. Burns, et al., "Inhibition of Alkali-Induced Corneal Ulceration and Perforation by a Thiol Peptide", Invest. Ophthalmol. Vis. Sci. 31:107-114 (1990).
A. Henney, et al., "Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization", Proc. Natl. Acad. Sci. USA 88:8154-8158 (1991).
J. D'Arniento, et al., "Collagenase Expression in the Lungs of Transgenic Mice Causes Pulmonary Emphysema", Cell 71:955-961 (1992).

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