Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

Details Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

1984-05-25

1985-12-24

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

548533, 548201, 548470, 548452, 548147, 548379, 548315, 546205, 546260, 260239A, 260112R, 544349, C07C10352, C07D20700, C07D27704, C07D20944, C07D21106, C07D21322, C07D24136, C07D20902, C07D27760, C07D23106, C07D, C07D40330, C07D49900, C07G 700

Patent

active

045605068

ABSTRACT:
Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.

REFERENCES:
patent: 4248883 (1981-02-01), Sawayama et al.
patent: 4440941 (1984-04-01), Suh et al.
patent: 4456595 (1984-06-01), Weller et al.
patent: 4499079 (1985-02-01), Gordon et al.
Biochem. Biophys. Res. Commun. 125 82-89, (1984).

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