Mercaptoacyl derivatives of substituted prolines

Details Mercaptoacyl derivatives of substituted prolines Mercaptoacyl derivatives of substituted prolines

1980-10-31

1982-02-23

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2603262, 26032643, 26032647, 26032625, 26032622, 424240, 424246, 424250, 424251, A61K 3140, C07D20712

Patent

active

043169066

ABSTRACT:
New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
Neuberger, "The Stereochemistry of Hydroxyprolines", J. Chem. Soc., (1945) pp. 429-432.
Patchett, et al., "Studies on Hydroxyproline", J. Amer. Chem. Soc., vol. 79, pp. 185-192 (1957).
Baer, "Derivatives of Hydroxy-L-Proline," Can. J. Biochem. Physiol., vol. 37, pp. 583-587 (1959).
Sheehan et al., "The Synthesis of cis and trans 3-Hydroxy-L Proline," J. Amer. Chem. Soc., vol. 85, p. 3863, 1963.
Magerlein, "Lincomycin VII . . . ", J. Med. Chem., vol. 10, pp. 1161-1163, (1967).
Mauger, et al., "Analogs and Homologs of Proline and Hydroxyproline", Chem. Rev., vol. 66, pp. 47-86, 1966.

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