Mercapto-substituted pyridine compounds

Details Mercapto-substituted pyridine compounds Mercapto-substituted pyridine compounds

1990-01-29

1992-12-01

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546290, 546298, C07D21389

Patent

active

051681137

ABSTRACT:
A mercapto-substituted pyridine compound having formula (I): ##STR1## where R.sub.1 and R.sub.2 are alkyl groups, and n is 0 or 1, and salts thereof and a process for preparing the same are disclosed. The mercapto-substituted pyridine compound is useful as an intermediate for preparing a herbicidal compound.
The present invention further provides aminocarbonyl-substituted pyridinesulfinic acid (ACPS) or salts thereof as the precursor of aminosulfonyl-substituted pyridinecarbonic acid amide compound (APCA) which is useful as the starting material for agricultural chemicals, medicine, etc. Moreover, the preparation process of the present invention is an industrially advantageous preparation process which is capable of preparing in a series of steps from mercapto-substituted pyridinecarboxylic acid amide compound (MPCA) or aminocarbonyl-substituted halogenopyridine compound (ACHP) to ACPS or salts thereof, and further to APCA.

REFERENCES:
patent: 3759932 (1973-09-01), Gavin et al.
patent: 4435206 (1984-03-01), Levitt
patent: 4518776 (1985-05-01), Meyer et al.
patent: 4521597 (1985-06-01), Kristinsson et al.
patent: 4548942 (1985-11-01), Shroot et al.
patent: 4786734 (1988-11-01), Hanagan
Blank et al., "Mercaptopyridinecarboxylic Acids, Synthesis and Hypoglycemic Activity"; Journal of Medicinal Chemistry; vol. 17, No. 10, pp. 1065-1071; 1974.
Blank et al., "Synthesis and Hypoglycemic Activity of 4-Substituted 3-Mercaptopicolinic Acids", Journal of Medicinal Chemistry; vol. 20, No. 12, pp. 1572-1577, 1977.

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