Mercapto-bicycloheterocyclics useful as intermediates for penem

Details Mercapto-bicycloheterocyclics useful as intermediates for penem Mercapto-bicycloheterocyclics useful as intermediates for penem

1988-01-11

1990-10-09

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546119, 546121, 540227, 540310, 548128, 548178, 548217, 548258, 5482624, 548324, 548369, 548453, C07D23502, C07D24916

Patent

active

049622021

ABSTRACT:
New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporing antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, .beta.-lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.

REFERENCES:
patent: 4748162 (1988-05-01), Leanza et al.
Chemical Abstracts vol. 110:75160a, Takemura et al., JP 63, 154,691 (1987).
Chemical Abstract vol. 106:213640c, Sato et al., EP 210,883 (1987).

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