Mercapto acyl-carnitines and pharmaceutical compositions contain

Details Mercapto acyl-carnitines and pharmaceutical compositions contain Mercapto acyl-carnitines and pharmaceutical compositions contain

1982-03-19

1986-06-03

Garner, Vivian

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

2604025, 260390, 424DIG13, 560147, 560 16, 560 15, 560125, 514529, A61K 3122, A61K 3123, C07C149243

Patent

active

045930430

ABSTRACT:
A novel class of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These mercapto acyl-carnitines are prepared, e.g., by first preparing the corresponding halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the --SH group for the halogen atom.
These mercapto acyl-carnitines are useful therapeutic agents, e.g., for the treatment of intoxications and burns and as mucolytic agents. Dithio diacyl carnitines and hydrochloride salts thereof, which are intermediates, are also disclosed.

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