Meningococcal polysaccharide conjugate vaccine

Details Meningococcal polysaccharide conjugate vaccine Meningococcal polysaccharide conjugate vaccine

1994-05-05

1996-11-19

Kim, Kay K. A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241931, 4242031, 530403, 530405, 530409, 530411, 536 551, 536 187, A61K 39385, A61K 39116, C07K 1710, C08B 3700

Patent

active

055760023

ABSTRACT:
Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.

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