Meningococcal polysaccharide conjugate vaccine

Details Meningococcal polysaccharide conjugate vaccine Meningococcal polysaccharide conjugate vaccine

1997-10-17

1999-05-11

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241831, 42419711, 4242031, 5303871, A61K39/395

Patent

active

059025867

ABSTRACT:
Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.

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