Meningeal-derived stem cells

Details Meningeal-derived stem cells Meningeal-derived stem cells

2003-06-10

2008-08-12

Saucer, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S368000, C435S377000

Reexamination Certificate

active

07410797

ABSTRACT:
Stem cell lines derived from meningeal tissue such as dura mater, pia mater, or arachnoid mater, are disclosed. In various embodiments, the stem cell lines include greater than 80%, greater than 90%, or greater than 99% of pluripotent meningeal-derived stem cells. In other embodiments, the stem cell lines are induced to form nerve cells, bone cells, cartilage cells, Schwann cells, adipocytes, fibroblasts, or melanocytes with various inducing agents, such as antioxidants, steroid hormones, laminin, or various growth factors. Derivation of the current stem cell lines is accomplished through explantation or enzymatic dissociation of meningeal tissue, followed by expansion to large populations using growth media.

REFERENCES:
patent: 5356807 (1994-10-01), Blass et al.
patent: 5605938 (1997-02-01), Roufa et al.
patent: 5658786 (1997-08-01), Smith et al.
patent: 5849585 (1998-12-01), Mather et al.
patent: 5912259 (1999-06-01), Carroll et al.
Lam RMY et al. 1981. Osteosarcoma of meninges: clinical, light, and ultrastructural observations of a case. Am J Surg Path 5: 203-208.
Oruckaptan HH et al. 2001. Parafalcine chondrosarcoma: an unusual localization for a classical variant. Surg Neurol 55: 174-179.
Sugita Y et al. 2000. Primary meningeal sarcomas with leiomyoblastic differentiation. Am J Surg Path 24: 1273-1278.
Salibi SS et al. 1989. Lipomeningioma: report of three cases and review of the literature. Neurosurgery 25: 122-126.
Tamamaki N. 2002. Radial glias and radial fibers: what is the function of radial fibers? Anat Sci International 77: 2-11.
Horwitz EM. 2003. Stem cell plasticity: the growing potential of cellular therapy. Arch Med Res 34: 600-606.
L.A. Opperman et al., “Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures,”Dev. Dynamics, 198(4):312-322 (1993).
D.B. Drake et al., “Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications,”J. Craniofacial Surg., 4(2):85-90 (1993).
C.S. Potten et al., “Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt,”Development—Supp., 110(4):1001-20 (1990).
G.M. Morriss-Kay, “Derivation of the mammalian skull vault,”J. Anat., 199:143-151 (2001).
S.S. Tholpady et al., “Mesenchymal Stem Cells From Rat Visceral Fat Exhibit Multipotential Differentiation In Vitro,”Anat. Rec., 272A:398-402 (2003).
Greenwald, Joshua A. et al., “Regional Differentiation of Ctanial Suture-Associated Dura Mater In Vivo and In Vitro: Implications for Suture Fusion and Patency,”Journal of Bone and Mineral Research, vol. 15, No. 12, pp. 2413-2430, (2000).
Woodbury, Dale, et al., “Adult Rat and Human Bone Marrow Stromal Cells Differentiate Into Neurons,”Journal of Neuroscience Research, 61:364-370 (2000).
Sanchez-Ramos et al., “Differentiation of Neuron-like Cells from Bone Marrow Stromal Cells,”Movement Disorders, vol. 13, supplement 2, p. 122 (1998). Abstract Only.
Pittenger et al., “Multilineage Potential of Adult Human Mesenchymal Stem Cells,”Science, vol. 284, pp. 143-147 (1999).
S. S. Tholpady, et al., Mesenchymal Stem Cells From Rat Visceral Fat Exhibit Multipotential Differentiation In Vitro, The Anatomical Record Part A, Wiley-Liss, Inc., pp. 398-402, (2003).
Mark F. Pittenger, et al., Multilineage Potential of Adult Human Mesenchymal Stem Cells, SCIENCE, pp. 143-147, (Apr. 2, 1999).
Patricia A. Zuk, Ph.D., et al., Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies, Tissue Engineering, vol. 7 (No. 2), pp. 211-228, (2001).

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