Memory enhancing and anti-dementia agent containing dehydroevodi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31505

Patent

active

058590161

ABSTRACT:
Dehydroevodiamine-HCl, a constituent of Evodia rutaecarpa Benth. (DHED) exhibits anti-AChE activity and improves the memory impairment of animals produced by scopolamine in the passive avoidance test. Thus, DHED can be a potent, long term memory enhancing and anti-dementia agent if it is used together with a pharmaceutically acceptable carrier.

REFERENCES:
S. Loh et al., "Ionic Mechanisms Responsible for the Antiarrhythmic Action of Dehydroevodiamine in Guinea-pig Isolated Cardiomycites", Br. J. Pharmacol., 106:517-523 (1992).
C.B. Millard et al., "Anticholinesterases: Medical Applications of Neurochemical Principles", J. Neurochem., 64(5):1909-1918 (1995).
Y. Kanaoka et al., "Polyphosphate Ester as a Synthetic Agent", Chem. Pharm. Bull. 15(1):101-107 (1967).
A. Haji et al., "Increased Feline Cerebral Blood Flow Induced By Dehydroevodiamine Hydrochloride From Evodia Ruttaecarpa.sup.1 ", J. Nat. Prod., 57(3):387-389 (1994).
M. Yang et al., "The Hypotensive and Negative Chronotropic Effects of Dehydroevodiamine", Euro. J. Pharm., 182:537-542 (1990).
H. Yang et al., "Hypotensive Effects of Dehyroevodiamine, A Quinazolino-carboline Alkaloid Isolated From Evodiae Rutaecarpa Rutaecarpa", Asia Pacific Journal of Pharmacology, 3:191-196 (1988).
N. Whittaker et al., "The Synthesis of Emetine and Related Compounds", J. Chem. Soc. pp. 85-89 (1969).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Memory enhancing and anti-dementia agent containing dehydroevodi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Memory enhancing and anti-dementia agent containing dehydroevodi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Memory enhancing and anti-dementia agent containing dehydroevodi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1516262

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.