Membrane-type matrix metalloproteinase-5 gene

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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435226, 4352523, 536 232, C12N 1557, C12N 964

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active

058375082

ABSTRACT:
HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arhritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.

REFERENCES:
EST #808618 (1997).
Puente, Xoze S., et al. "Molecular Cloning of a Novel Membrane-type Matrix Metalloproteinase from a Human Breast Carcinoma", Cancer Research 56, 944-949, Mar. 1, 1996.
Yamada, T., et al. "White matter microglia produce membrane-type matrix metalloprotease, an of gelatinase A, in human brain tissues", Acta Neuropathol (1995) 90:421-424.
Okada, A., et al. "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stomal cells of human colon, breast, and head and neck carcinomas", Proc. Natl. Acad. Sci. USA, vol. 92, pp. 2730-3734, Mar. 1995, Medical Sciences.
Atkinson, Susan J., et al. "Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progela Progelatinase A by Cell Membranes", The Journal of Biological Chemistry, vol. 270, No. 51, Issue of Dec. 22, pp. 30479-30485, 1995.
Cao, Jian, et al. "The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a functional Transmembrane Domain Required for Pro-gelatinase A Activation", The Journal of Biological Chemistry, vol. 270, No. 2, Issue of Jan. 13, pp. 801-805, (1995).
Gilles, Christine, et al. "High Level of MT-MMP Expression is Associated with Invasiveness of Cervical Cancer Cells", Int. J. Cancer: 65, 209-213 (1996).
Imai, Kazushi, et al. "Membrane-Type Matrix Metalloproteinase 1 Is a Gelantinolytic Enzyme and Is Secreted in a Complex with Tissue Inhibitor of Metalloproteinases 2.sup.1 ", Cancer Research 56, 2707-2710, Jun. 15, 1996.
Nomura, Hidehiro, "Expression of Membrane-Type Matrix Metalloproteinase in Human Gastric Carcino Carcinomas", Cancer Research 55, 3263-3266, Aug. 1, 1995.
Strongin, Alex Y., "Plasma Membrane-dependent Activation of the 72-kDa Type IV Collagenase Is Prevented by Complex Formation with TIMP-2", The Journal of Biological Chemistry, vol. 268, No. 19, Issue of Jul. 5, pp. 14033-14039, (1993).
Tokuraku, Masato, et al., "Activation of the Precursor of Gelatinase A/72 kDa Type IV Collagenase/MMP-2 In Lung Carcinomas Correlates with the Expression of Membrane-Type Matrix Metalloproteinase (MT-MMP) and With Lymph Node Metastasis", Int. J. Cancer (Pred. Oncol.): 64, 335-359 (1995).
Will, Horst, et al., "The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates autoproteolytic Activation", The Journal of Biological Chemistry, vol. 271, No. 29, Issue of Jul. 19, pp. 17119-17123, 1996.
Yamamoto, Masaaki, et al. "Differential Expression of Membrane-Type matrix Metalloproteinase and Its Correlation with Gelatinase A Activation in human Malignant Brain Tumors in Vivo and in Vitro", Cancer Research 56, 384-392, Jan. 15, 1996.
Takino, Takahisa, "Identification of the Second Membrane-type Matrix Metalloproteinase (MT-mmp-2) Gene from a Human Placenta cDNA Library", The Journal of Biological Chemistry, vol. 270, No. 39, Issue of Sep. 29, pp. 23013-23020, (1995).
Will, Horst, et al., "cDNA sequence and mRNA tissue distribution of a novel human matrix metallopote metalloproteinase with a potential transmembrane segment", Eur. J. Biochem. 231, 602-608 (1995).
Sato, Hiroshi, et al., "A matrix metalloproteinase expressed on the surface of invasive tumor cells", Nature, vol. 370, Jul. 7, 61-64.

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