Membrane, system and process for testing substance diffusion thr

Details Membrane, system and process for testing substance diffusion thr Membrane, system and process for testing substance diffusion thr

1987-04-14

1989-03-14

Jones, Larry

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435285, 324444, C12M 134

Patent

active

048124079

ABSTRACT:
The system for testing the diffusion behavior of a substance comprises a donor compartment detachably mounted on a holding member of a rotor, rotatably around a vertical axis, said donor compartment being bounded at its bottom by a membrane effective to separate the donor compartment from an acceptor compartment. The membrane comprises a flexible carrier of a bio-compatible, lifeless, light permeable material, on which cells constituting a monocellular layer have been cultivated, for example. By determining the time dependent variation of the quantity of a substance passing through the membrane by diffusion, it is possible to determine the coefficient of diffusion and/or the coefficient of permeability of the membrane and of the cell culture provided thereon. By suitable selection of the cells, conditions may be created that closely resemble those that occur during the absorption of the respective substance through the biophase of a living organism.

REFERENCES:
patent: 3275528 (1966-09-01), Ainis
patent: 4251631 (1981-02-01), Simon
patent: 4296205 (1981-10-01), Verna
patent: 4686190 (1987-08-01), Cramer et al.
"Theoretical and Experimental Studies of Transport of Micelle-Solubilized Solutes", by Gregory E. Amidon, William T. Higuchi & Norman F. H. Ho, Accepted for publication Apr. 27, 1981. Journal of Pharmaceutical Sciences, vol. 71, No. 1, Jan. 1982.

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