Membrane proteins and peptides of haemophilus influenzae type B

Details Membrane proteins and peptides of haemophilus influenzae type B Membrane proteins and peptides of haemophilus influenzae type B

1993-09-20

1999-06-29

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

435 691, 4351723, A61K 3902

Patent

active

059165626

ABSTRACT:
The nucleotide sequence of the P2 gene and the derived amino acid sequence of the P2 protein of Haemophilus influenzae type b are disclosed and the methods used to determine the same. Also disclosed are the methods used to clone and express the P2 gene as well as the purification protocol for the gene and protein. Also disclosed is the synthesis of peptides corresponding to the N-terminal and C-terminal ends of the P2 protein. Also disclosed is the use of the P2 protein as a protective agent for the disease caused by Haemophilus influenzae type b and the use of the protein as a carrier for conjugation with an oligosaccharide derived from Haemophilus to generate a potentially efficacious vaccine against the disease. Also disclosed is the use of P2 peptide-conjugates as immunising agents.

REFERENCES:
patent: 4762713 (1988-08-01), Anderson et al.
patent: 5098997 (1992-03-01), Anilionis et al.
Munson et al., J. Clin. Invest., vol. 72, 1983, pp. 677-684.
J.Clin.Invest, vol. 72, Aug. 1983, pp. 677-684, Robert S. Munson Jr. et al., "Purification and Comparison of Outer Membrane Protein P2 from Haemophilus Influenzae Type b Isolates".

Affiliated with

Also associated with

Rating

Membrane proteins and peptides of haemophilus influenzae type B does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Membrane proteins and peptides of haemophilus influenzae type B, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Membrane proteins and peptides of haemophilus influenzae type B will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1373787