Membrane-permeant phosphoinositides

Details Membrane-permeant phosphoinositides Membrane-permeant phosphoinositides

1998-04-24

1999-09-21

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514100, 514118, 514120, 514121, 514129, 549220, 558157, 558160, 558161, 558179, 558180, 558185, 558186, A61K 3166, C07F 910, C07F 9117, C07F 9177, C07F 924

Patent

active

059554533

ABSTRACT:
Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated with the membrane-permeant phosphoinositide, which is then absorbed into the cell. The neutralizing groups can be removed intracellularly to afford the charged phosphoinositide.

REFERENCES:
patent: 5866548 (1999-02-01), Tsien et al.

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