Membrane Na.sup.+ channel protein and related therapeutic compo

Details Membrane Na.sup.+ channel protein and related therapeutic compo Membrane Na.sup.+ channel protein and related therapeutic compo

1992-07-20

1998-05-12

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

514 85, C07D24102

Patent

active

057506973

ABSTRACT:
A channel protein having a Na.sup.+ /K.sup.+ selectivity of approximately 100 and capable of affecting Na.sup.+ membrane transport is disclosed. Amiloride derivatives, and amiloride gel materials incorporating such derivatives, useful in treating membrane transport, cellular volume and cellular pressure disorders and in isolating the channel protein are also disclosed. These amiloride derivatives may be prepared by mixing the amiloride with an alkanediol in the presence of a base followed by addition of an acid. Use of the channel protein in diagnostic assays and screening assays is described.

REFERENCES:
patent: 4894376 (1990-01-01), Morad et al.
patent: 4895807 (1990-01-01), Cherksey
patent: 4898729 (1990-02-01), Miller et al.
patent: 4950591 (1990-08-01), Cherksey
patent: 5132296 (1992-07-01), Cherksey

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