Membrane NA+ channel protein and related therapeutic compounds

Details Membrane NA+ channel protein and related therapeutic compounds Membrane NA+ channel protein and related therapeutic compounds

1990-04-30

1992-07-21

Johnston, Jill A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514 54, 514 59, 536 41, 536 56, 536112, A61K 3170, A61K 31715

Patent

active

051322960

ABSTRACT:
A channel protein having a Na.sup.+ /K.sup.+ selectivity of approximately 100 and capable of affecting Na.sup.+ membrane transport is disclosed. Amiloride derivatives, and amiloride gel materials incorporating such derivatives, useful in treating membrane transport, cellular volume and cellular pressure disorders and in isolating the channel protein are also disclosed. Use of the channel protein in diagnostic assays and screening assays is described.

REFERENCES:
patent: 4898729 (1990-02-01), Miller et al.

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