Membrane having high affinity for low density lipoprotein-choles

Details Membrane having high affinity for low density lipoprotein-choles Membrane having high affinity for low density lipoprotein-choles

1990-11-27

1993-02-16

Page, Thurman K.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Rod, strand, filament or fiber

428364, 428373, 428378, 428400, 521 27, 21050023, B01D 6302, B01D 6908

Patent

active

051870100

ABSTRACT:
The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to the use of an immobilized affinity agent on a microporous plasmapheresis membrane. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.

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patent: 4938778 (1990-07-01), Ohyabu
patent: 4940541 (1990-07-01), Aoyagi
Thies et al., Artificial Organs 12, pp. 320-324 1988.
Naito, Ito et al., Artificial Organs vol. 13, pp. 190-196, 1989.
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Tabak et al., Life Support Systems, vol. 4, pp. 355-365 (1986).
Ostlund, Artificial Organs, vol. 12, 491-496 (1988).
Parker et al., Methods in Enzymology, vol. 137, pp. 466-478 (1988).
Kochinke et al., J. Membrane Science, vol. 36, pp. 101-117 (1988).
Klinkmann et al., J. of Art. Org., vol. 12, pp. 207-210 (1989).

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