Membrane fusion proteins derived from reovirus

Details Membrane fusion proteins derived from reovirus Membrane fusion proteins derived from reovirus

2007-12-07

2010-12-14

Lucas, Zachariah (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C424S215100

Reexamination Certificate

active

07851595

ABSTRACT:
In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.

REFERENCES:
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Attwood et al, The Babel of bioinformatics. Science (2000) vol. 290, No. 5491, PDF having pp. 1-7).
Shmulevitz et al. (The EMBO Journal, vol. 19, p. 902-912.

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