Membrane countercurrent exchanger and membrane inlet mass...

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

Reexamination Certificate

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C073S019050, C250S281000, C250S288000, C436S052000, C436S068000, C436S133000, C436S136000, C436S138000, C436S139000, C436S174000, C436S178000, C436S181000

Reexamination Certificate

active

07087436

ABSTRACT:
A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other liquid in a manner independent of the solubility of the gases in the blood or other liquid. A countercurrent membrane exchanger (CCME) is provided for equilibrating a carrier fluid with the sample of blood or other liquid, the output of which is coupled to a tubular direct insertion membrane probe (t-DIMP) type of membrane inlet mass spectrometer. The CCME preferably has complementary spiral grooves on opposing metal plates for the water carrier and sample liquids so as to induce secondary flows which greatly reduce the resistance to equilibration between the liquid sample and water carrier phases. The t-DIMP is characterized by the use of Teflon™ sleeves specifically to reduce noise introduced at the connection between the silicone membrane in the t-DIMP and the steel tubing for the water carrier, by the use of radiation shields to prevent heating of the silicone membrane and water carrier to allow lower carrier flow rates, and by the heating of the section between the ion source and the vacuum pumps specifically to improve linearity of the t-DIMP.

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