Membrane channel protein and related therapeutic compounds

Details Membrane channel protein and related therapeutic compounds Membrane channel protein and related therapeutic compounds

1986-12-31

1990-01-23

Richman, Barry S.

Chemistry: analytical and immunological testing

Biological cellular material tested

435 7, 436531, 530350, 530395, 530400, 530417, 530813, 530828, 530835, 530839, 530841, 530844, G01N 33483, C07K 302, C07K 320, C07K 1500

Patent

active

048958077

ABSTRACT:
A channel protein has a molecular weight of approximately 280 kD and is capable of affecting K.sup.+ and Cl.sup.- membrane transport. Furosemide and quinine derivatives, and polysaccharide or monosaccharide gels incorporating such derivatives, are useful in treating membrane transport, cellular volume and cellular pressure disorders and in producing the channel protein. The channel protein is used in diagnostic assays and screening assays is described.

REFERENCES:
patent: 4362737 (1982-12-01), Shafer et al.
Dialog Record No. 07203578; Embase Abstract No. 88201968.
Dialog Record No. 0018692255; Biosis Abstract No. 86094730.
Dialog Record No. 0018649248; Biosis Abstract No. 86072616.
Dialog Record No. 0018587734; Biosis Abstract No. 86043968.

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