Membrane calcium channels and factors and methods for blocking,

Details Membrane calcium channels and factors and methods for blocking, Membrane calcium channels and factors and methods for blocking,

1988-07-14

1990-08-21

Warden, Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424537, 424538, 530413, 530858, C07K 320, C07K 1508

Patent

active

049507397

ABSTRACT:
Nonpolypeptide factors isolated from the venom of funnel-web spiders are capable of binding calcium channel proteins. These nonpolypeptide factors are used to purify calcium channels and completely block voltage-dependant calcium conductance of cell membranes.

REFERENCES:
Nevalainen, et al., Biomedical Research 8(2), 1987, pp. 89-93.
Adams, et al., Proceedings of the Australian Physiological and Pharmacological Society 7, 1976, p. 161p.
Cherksey, et al., Soc Neurosci Abstr 14(2), 1988, p. 901.
Strassberg, J. et al., Toxicon, 1:41, 1962.
Meadow, et al., Toxicon, 8:311-312.
Gregson, R. P. et al., Comp. Biochem. Physiol., 74C (1):125-132, 1983.
Scheumack, D. D., et al., Febs. LETTERS, 181 (1):154-156, 1985.
Jackson, H. et al., Neuroscience Abstracts, 1985 p. 107, 32.17 in Excitatory Amino Acids: Physiol. and Pharm.
Curtis, B. M., et al., Biochem. 1986, 25:3077-3083.
Adams, M. E., et al., Insect Neurophysiol. Pap. Int. Conf. Second, 1986, pp. 397-400.
Jackson, H. et al., Presynaptic Blockade of Transmission By A Protent, Long-Lasting Toxin From A. aperta, Soc. Neurosci. Abstr. 12:730, 1986.
Jackson, H. et al., In Excitatory Amino Acid Transmission, 1987 (Alan R. Liss, Inc.) pp. 51-54.
Miller, R. J., Science 235:46, 1987.
Bowers, C. W. et al., PNAS (U.S.A.) 84:3506, 1987.
Sugimori, M. et al., Soc. Neurosci. Abstr., 13:228, 1987.
Kerr, L. M., et al., Soc. Neurosci. Abstr. 13:102, 1987.
Lai, F. A. et al., Nature, 331-315, 1988.
Spence, J. Neurotoxins, Fundam. Clin. Adv. (Int'l Conf.), 1979.
Jackson, H. et al., TINS, 11:278, 1988.

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