Membrane-associated immunogens of mycobacteria

Details Membrane-associated immunogens of mycobacteria Membrane-associated immunogens of mycobacteria

1992-06-29

1994-07-19

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

530350, 435 693, 435195, 514 2, 536 237, 4242481, C07K 1300, C07K 1504, A61K 3904

Patent

active

053307542

ABSTRACT:
Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA, constructed in pBR322 vector, and screened with sera collected from tuberculosis patients. The BCG DNA insert of one of the recombinants, pMBB51A, which expressed an antigen of Mr 90 kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The approach described here can be used to identify immunogens of mycobacteria. In addition, the well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. Also, the promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

REFERENCES:
Rumschlag, A. A., et al. (1990) A. Clin. Micro. 28:591-5.
Wood, W. I. (1987) Meth. Enzymol. 152:443-7.
Young, D. B. et al. (1987) Infect. Immun. 55:1421-26.
Bloom, et al., Science, 257:1055-1063 (1992).
Rastogi, et al., Clinical Infectious Diseases, 14:308-312 (1992).
Fine, et al., The Lancet, Aug. 30, pp. 499.circleincircle.(1986).
Chaparas, et al., American Review of Respiratory Disease, 122:533-542 (1980).
Hopwood, et al., British Medical Bulletin, 44:528-546 (1988).
Bloom, International Journal of Leprosy, 58:365-375 (1990).
Kaufmann, Res. Microbiol., 141:765-768 (1990).
Falla, et al., Infection and Immunity, 59:2265-2273 (1991).
Bermudex, et al., Infection and Immunity, 59:1697-1702 (1992).
Havlir, et al., Infection and Immunity, 59:665-670 (1991).
Sussman, et al., Infection and Immunity, 59:2828-2835 (1991).
Blanchard, et al., Infection and Immunity, 59:2396-2402 (1991).
Denis, Clin. exp. Immunol., 83:466-471 (1991).
Wadee, et al., Infection and Immunity, 57:864-869 (1989).
Pedrazzini, et al., The Journal of Immunology, 139:2032-2037 (1987).
Ramasesh, et al., Infection and Immunity, 59:2864-2869 (1991).
Praputpittaya, et al., Clin, exp. Immunol., 70:298-306 (1987).
Bradley, Journal of Bacteriology, 113:645-651 (1973).
Imaeda, et al., International Journal of Systematic Bacteriology, 32:456-458 (1982).
Imaeda, International Journal of Systematic Bacteriology, 35:147-150 (1985).
Garcia, et al., Journal of General Microbiology, 132:2265-2269 (1986).
Wasem, et al., Journal of Clinical Microbiology, 29:264-271 (1991).
Eisenach, et al., Am Rev Respir Dis, 133:1065-1068 (1986).
Minden, et al., Infection and Immunity, 46:519-525 (1984).
Closs, et al., Scand. J. Immunol., 12:249-263 (1980).
Daniel, et al., Microbiological Reviews, 42:84-113 (1978).
Engers, et al., Infect. Immun., 51:718-720 (1986).
Engers, et al., Infect. Immun., 48:603-605 (1985).
Ljungqvist, et al., Infection and Immunity, 56:1994-1998 (1988).
Kadival, et al., Journal of Clinical Microbiology, 25:76-80 (1987).
Rouse, et al., Infection and Immunity, 58:1445-1449 (1990).
Worsaae, et al., Journal of Clinical Microbiology, 26:2608-2614 (1988).
Coates, et al., The Lancet, Jul. 25, pp. 167-169 (1981).
Young, et al., Nature, 316:450-452 (1985).
Young, et al., Proc. Natl. Acad. Sci. USA, 82:2583-2587 (1985).
Shinnick, et al., Infection and Immunity, 55:1932-1935 (1987).
Shinnick, et al., Infection and Immunity, 55:1718-1721 (1987).
Husson, et al., Proc. Natl. Acad. Sci. USA, 84:1679-1683 (1987).
Lu, et al., Infection and Immunity, 55:2378-2382 (1987).
Young, et al., Proc. Natl. Acad. Sci. USA, 80:1194-1198 (1983).
Matsuo, et al., Journal of Bacteriology, 170:3847-3854 (1988).
Yamaguchi, et al., FEBS Letters, 240:115-117 (1988).
Yamaguchi, et al., Infection and Immunity, 57:283-288 (1989).
Radford, et al., Infection and Immunity, 56:921-925 (1988).
Harboe, et al., Infection and Immunity, 52:293-302 (1986).
Minden, et al., Infection and Immunity, 53:560-564 (1986).
Thole et al., Infection and Immunity, 50:800-806 (1985).
Jackett, et al., Journal of Clinical Microbiology, 26:2313-2318 (1988).
Chandramuki, et al., Journal of Clinical Microbiology, 27:821-825 (1989).
Suzuki, et al., FEMS Microbiology Letters, 44:73-76 (1987).
Katoch et al., Proceedings of Indo-UK Symposium, pp. 262-269, (1986).
Medow, et al., Zbl. Bakt. Hyg. A, 266:359-369 (1987).
Sela, et al., Journal of Bacteriology, 171:70-73 (1989).
Ramakrishnan, Proceedings of Indo-UK Symposium, pp. 254-261, (1986).
Bhargava, et al., Journal of Bacteriology, 172:2930-2934 (1990).
Snider, et al., AM REV RESPIR DIS, 130:1095-1099 (1984).
Jones, et al., AM REV RESPIR DIS, 125:640-643 (1982).
Bolivar, et al., Gene, 2:95-113 (1977).
Sharp, et al., Nucleic Acids Research, 16:8207-8210 (1988).
Young, et al., Molecular Microbiology, 6:133-145 (1992).
Collins, et al., FEMS Microbiology Letters, 43:53-56 (1987).
Parra, et al., Infection and Immunity, 59:3411-3417 (1991).
Young, et al., Infection and Immunity, 55:1421-1425 (1987).
Andersen, et al., Infection and Immunity, 56:1344-1351 (1988).
Jacobs, et al., Infection and Immunity, 52:101-109 (1986).
Cohen, et al., Journal of Clinical Microbiology, 25:1176-1180 (1987).
Shinnick, et al., Nucleic Acids Research, 17:1254 (1989).
Verbon, et al., Journal of Bacteriology, 174:1352-1359 (1992).
Kingston, et al., Infection and Immunity, 55:3149-3154 (1987).
Ashbridge, et al., Nucleic Acids Research, 17:1249 (1989).
Lamb, et al., Eur. J. Immunol., 18:973-976 (1988).
Borremans, et al., Infection and Immunity, 57:3123-3130 (1989).
De Wit, et al., Nucleic Acids Research, 18:3995 (1990).
Vismara, et al., Infection and Immunity, 58:245-251 (1990).
Rumschlag, et al., Journal of Clinical Microbiology, 28:591-595 (1990).
Thole, et al., Infection and Immunity, 58:80-87 (1990).
Andersen, et al., Infection and Immunity, 57:2481-2488 (1989).
Kadival, et al., The Journal of Immunology, 139:2447-2451 (1987).
Praputpittaya, et al., Clin. Exp. Immunol., 70:307-315 (1987).
Young, et al., Infection and Immunity, 54:177-183 (1986).
Emmrich, et al., J. Exp. Med., 163:1024-1029 (1986).
Mehra, et al., Proc. Natl. Acad. Sci. USA, 83:7013-7017 (1986).
Oftung, et al., The Journal of Immunology, 141:2749-2754 (1988).
Buchanan, et al., Infection and Immunity, 55:1000-1003 (1987).
Anderson, et al., The Journal of Immunology, 141:607-613 (1988).
Garsia, et al., Infection and Immunity, 57:204-212 (1989).
Britton, et al., J. Exp. Med., 164:695-708 (1986).
Peake, et al., The Journal of Biological Chemistry, 266:20828-20832 (1991).
Davenport, et al., Infection and Immunity, 60:1170-1177 (1992).
Content, et al., Infection and Immunity, 59:3205-3212 (1991).
Abou-Zeid, et al., Infection and Immunity, 59:2712-2718 (1991).
Wiker, et al., Infection and Immunity, 58:272-274 (1990).
Davis, et al., Journal of Bacteriology, 173:5653-5662 (1991).
Suzuki, et al., Journal of Bacteriology, 170:2886-2889 (1988).
Young, et al., Infection and Immunity, 59:3086-3093 (1991).
Lathigra, et al., Nucleic Acids Research, 16:1636 (1988).
Baird, et al., Nucleic Acids Research, 16:9047 (1988).
Patel, et al., Journal of Bacteriology, 173:7982-7987 (1991).
Nerland, et al., Journal of Bacteriology, 170:5919-5921 (1988).
Flaherty, et al., Nature, 346:623-628 (1990).
Young, et al., Proc. Natl. Acad. Sci. USA, 85:4267-4270 (1988).
Nagai, et al., Infection and Immunity, 59:372-382 (1991).
Andersen, et al., Infection and Immunity, 59:1905-1910 (1991).
Fifis, et al., Infection and Immunity, 59:800-807 (1991).
Worsaee, et al., Infection and Immunity, 55:2922-2927 (1987).
Abou-Zeid, et al., Infection and Immunity, 56:3046-3051 (1988).
Abou-Zeid, et al., Journal of General Microbiology, 134:531-538 (1988).
Abou-Zeid, et al., Infection and Immunity, 55:3213-3214 (1987).
Thole, et al., Molecular Microbiology, 6:153-163 (1992).
Chatterjee, et

Affiliated with

Also associated with

Rating

Membrane-associated immunogens of mycobacteria does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Membrane-associated immunogens of mycobacteria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Membrane-associated immunogens of mycobacteria will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-518485