Member of the TNF ligand family

Details Member of the TNF ligand family Member of the TNF ligand family

2008-07-15

2008-07-15

Mondesi, Robert B. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S069100, C530S350000

Reexamination Certificate

active

09868533

ABSTRACT:
The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprising: i) a polypeptide having the amino acid sequence of FIG. (1) or ii) a variant of the polypeptide of i).

REFERENCES:
patent: 5595721 (1997-01-01), Kaminski et al.
patent: 6157933 (2000-12-01), Celi et al.
patent: 6716576 (2004-04-01), Yu et al.
patent: 0 869 180 (1998-10-01), None
patent: 869180 (1998-10-01), None
patent: 9828628.9 (1998-12-01), None
patent: WO98/18921 (1998-05-01), None
patent: WO 98 18921 (1998-05-01), None
patent: WO98/27114 (1998-06-01), None
patent: WO 98 27114 (1998-06-01), None
patent: WO 98/39361 (1998-09-01), None
patent: WO 98/55620 (1998-12-01), None
patent: WO98/55620 (1998-12-01), None
patent: WO 98 55620 (1998-12-01), None
patent: WO 98 55621 (1998-12-01), None
patent: WO98/55621 (1998-12-01), None
patent: WO 99/12964 (1999-03-01), None
patent: WO 00/43032 (2000-07-01), None
patent: WO 00/67034 (2000-11-01), None
patent: WO 01/12812 (2001-02-01), None
patent: WO 01/24811 (2001-04-01), None
patent: WO 02/066516 (2002-08-01), None
GenCore version 5.1.9, Copyright (c) 1993-2006 Biocceleration Ltd. OM protein-protein search, using sw model, Run on: Aug. 9, 2006, pp. 1-2.
Gruss, Molecular, structural and biological characteristics of the turmor necrosis factor ligand superfamily, Int'l of Clinical and Laboratory Research DE, Springer, Berlin 26(3):14-159 XP002094504 (1996).
Mukhopadhyay et al., J. Biol. Chem 274(23): 15978-15981 (Jun. 1999).
Schneider et al., J. Experimental Medicine 189(11):1747-1756 (Jun. 1999).
Gruss, H. J.,Molecular, structural, and biological characteristics of the tumor necrosis factor ligand suerfamily,International Journal of Clinical and Laboratory Research, DE, Springer, Berlin 23(3):14-159 XP002094504 (1996).
U.S. Appl. No. 09/302,863, filed Apr. 30, 1999, Goodwin et al.
U.S. Appl. No. 60/149,378, filed Aug. 17, 1999, MacKay et al.
U.S. Appl. No. 60/143,228, filed Jul. 9, 1999, MacKay et al.
U.S. Appl. No. 60/119,906, filed Feb. 12, 1999, Boyle et al.
U.S. Appl. No. 60/166,271, filed Nov. 18, 1999, Boyle et al.
U.S. Appl. No. 09/226,533, filed Jan. 7, 1998, Gross et al.
U.S. Appl. No. 60/058,786, filed Sep. 12, 1997, Jurg Tschopp.
U.S. Appl. No. 60/177,169, filed Jan. 25, 1999, MacKay et al.
von Bülow, et al., “NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily,”Science, 1997, vol. 278, pp. 138-141.
Laâbi, et al., “a New Gene, BCM, on Chromosome 16 is Fused to the Interleukin 2 Gene by a t(4;16)(q26;p13) Translocation in a Malignant T Cell Lymphoma,”EMBO Journal, 1992, vol. 11, pp. 3897-3904.
Laâbi, et al., “The BCMA Gene, Preferentially Expressed During B Lymphoid Maturation, is Bidirectionally Transcribed,”Nucleic Acids Research, 1994, vol. 22, pp. 1147-1154.
Madry, et al., “The Characterization of Murine BCMA Gene Defines it as a New Member of the Tumor Necrosis Factor Receptor Superfamily,”International Immunity, 1998, vol. 10, No. 11, pp. 1693-1702.
Gras, et al., “BCMAp: An Integral Membrane Protein in the Golgi Apparatus of Human Mature B Lymphocytes,”,International Immunity, 1995, vol. 7, No. 7, pp. 1093-1106.
MacKay, et al., “Mice Transgenic for BAFF Develop Lymphocytic Disorders Along with Autoimmune Manifestations,”J. Exp. Med., 1999, vol. 190, No. 11, pp. 1697-1710.
Moore, et al., “BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator,”Science, 1999, vol. 285, pp. 260-263.
Patel, et al., “Engineering an APRIL-specific B Cell Maturation Antigen,”The Journal of Biological Chemistry, 2004, vol. 279, No. 16, pp. 16727-16735.
Bodmer, et al., “The Molecular Architecture of the TNF Superfamily,”Trends in Biochemical Sciences, 2002, vol. 27, No. 1, pp. 19-26.
Hymowitz, et al., “Structures of APRIL-Receptor Complexes,”The Journal of Biological Chemistry, 2005, vol. 280, No. 8, pp. 7218-7227.
Xia, et al., “TACI is a TRAF-Interacting Receptor for TALL-I, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation,”J. Exp. Med., 2000, vol. 192, No. 1, pp. 137-143.
Gross, et al., “TACI and BCMA are Receptors for a TNF Homologue Implicated in B-Cell Autoimmune Disease,”Nature, 2000, vol. 404, pp. 995-999.
Thompson, et al., “BAFF Binds to the Tumor Necrosis Factor Receptor-like Molecule B Cell Maturation Antigen and is Important for Maintaining the Peripheral B Cell Population,”J. Exp. Med., 2000, vol. 192, No. 1, pp. 129-135.
Gross, et al., “TACI-1g Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease: Impaired B Cell Maturation in Mice Lacking BLyS,”Immunity, 2001, vol. 15, pp. 289-302.
Wallach, D., “TNF Ligand and TNF/NGF Receptor Families,”in Ligands, vol. 1, pp. 377-411 (eds. Oppenheim & Feldman).
Huard, et al., “T Cell Costimulation by the TNF Ligand BAFF,”The Journal of Immunology, 2001, vol. 167, pp. 6225-6231.
Huard, et al., “BAFF Production by Antigen-Presenting Cells Provides T Cell Co-Stimulation,”International Immunology, 2003, vol. 16, No. 3, pp. 467-475.
Ng, et al., “B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells1,”The Journal of Immunology, 2004, vol. 173, pp. 807-817.
Batten, et al., “The Role of BAFF in Autoimmunity: Is it Just a B Cell Story,”The 2005 Mid-Winter Conference of Immunologists at Asilomar, Jan. 22-25, 2005, Pacific Grove, CA (USA).
Davidson, et al., “Autoimmune Diseases,”The New England Journal of Medicine, 2001, vol. 345, No. 5, pp. 340-350 (eds. MacKay and Rosen).
Janeway, et al., “Chapter 12: Immune Responses in the Absence of Infection,”Immuno Biology—The Immune System in Health and Disease, 1997.
Tsokos, G., “Lymphocytes, Cytokines, Inflammation, and Immune Trafficking,”Current Opinion in Rheumatology, 1995, vol. 7, pp. 376-383.
Panayi, G.S., “The Pathogenesis of Rheumatoid Arthritis: From Molecules to the Whole Patient,”British Journal of Rheumatology, 1993, vol. 32, pp. 533-536.

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