Memantine-containing solid pharmaceutical dosage forms having an

Details Memantine-containing solid pharmaceutical dosage forms having an Memantine-containing solid pharmaceutical dosage forms having an

1993-07-23

1995-01-17

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Peptide containing

530360, 424465, 424469, 424470, A61K 938, A61K 964, A61K 3716

Patent

active

053826019

ABSTRACT:
The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release profile and which are characterized by the presence of both a water-soluble and a water-insoluble salt of casein, preferably sodium and calcium caseinate, in the matrix thereof, in broad proportions and in a total amount between 5 and 98% by weight of the composition, and with a process for the production thereof.

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Pharm. Acta Helv. 66, No. 4, 120-124 (1991), "Effect of Low-molecular Casein and Gelatin on Absorption of Ibuprofen after Oral and Rectal Administration"; S. Kimura, et al.
Pharmaceutical Technology 9, 360-374 (1990), "Influence of Sodium Caseinate on the Dissolution Rate of Hydrochlorothiazide and Chlorothiazide", F. C. Millar, et al.

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