Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2006-03-13
2009-10-20
Haddad, Maher M (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C530S350000
Reexamination Certificate
active
07605226
ABSTRACT:
The purpose of the present invention is to provide a novel protein involved in adhesion and fusion between myoblasts in the course of the formation of byotube. The present invention relates to Meltrins, which a membrane protein having fusion, adhesion and aggregation activity of cells, especially myoblast; and to polypeptides of their domains, DNAs encoding them, antisense RNA for these DNAs, various antibodies to Meltrins and the polypeptides of their domains, expression vectors containing these DNAs, and transformants by these vectors; as well as to the process for producing Meltrins and the polypeptides of their domains using those transformants and medical compositions comprising Meltrins or antagonist against them as an effective ingredient.
REFERENCES:
patent: 5883241 (1999-03-01), Docherty et al.
patent: 6191113 (2001-02-01), Nakahara et al.
patent: 7060791 (2006-06-01), Fujisawa et al.
patent: 97/31109 (1997-08-01), None
patent: 97/40072 (1997-10-01), None
Gilpin et al. A Novel, Secreted Form of Human ADAM 12 (Meltrin ) Provokes Myogenesis in Vivo . J. Biol. Chem. 1998 273: 157-166.
Paine et al. Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.. J Biol Chem. Nov. 15, 1992;267(32):22869-22876.
Murray RK et al. Harper's Biochemistry, 23ed., Prentic-Hall International Inc., London, 1993, p. 431.
Lewin B. Genes V, Oxford University Press, Oxford, 1994, pp. 281-282.
Alberts B et al., Molecular Biology of the Cell., Garland Publishing, Inc., New York 1994, pp. 628-629.
Office Action issued in corresponding Canadian Application No. 2,247,067, dated Jun. 13, 2005.
Nomura, N. et al., GenBank database entry, Accession # D14665, May 14, 1993.
Hillier, L. et al., GenBank database entry, Accession #R28537, Apr. 25, 1995.
S. Fujisawa, “Mouse mRNA for Meltrin Alpha”, EMBL Database Accession No. D50411, Sequence Identity MMMAB, Nov. 6, 1995, XP002151067.
S. Fujisawa, “Mouse mRNA for Meltrin Beta”, EMBL Database Accession No. D50410, Sequence Identity MMMBA, Nov. 6, 1995, XP002151068.
S. Fujisawa, “Mouse mRNA for Meltrin Gamma”, EMBL Database Accession No. D50412, Sequence Identity MMMGC, Nov. 6, 1995, XP002151069.
G. Weskamp et al., “MDC9, A Widely Expressed Cellular Disintegration Containing Cytoplasmic SH3 Ligand Domains”, The Journal of Cell Biology, vol. 132, No. 4, Feb. 1, 1996, 717-726, XP000644308, Rockefeller University Press.
N. Nomura et al., “Prediction of the Coding Sequences of Unidentified Human Genes. . .”, DNA Research, JP, Universal Academy Press, vol. 1, No. 1, 1994, 27-35, XP002049267.
N. Nomura et al., “Prediction of New Human Genes. . .”, EMBL Database Accession No. D14665, Sequence Identity HSORF09, Mar. 31, 1993, XP002151071.
“Cellular Disintegration-Related Protein Precursor”, SWISSPROT Database Accession No. Q13443, Nov. 1, 1996, XP002151071.
T. Yagami-Hiromasa et al., “A metalloprotease-disintegrin participating in myoblast fusion”, Nature 377, pp. 652-656, 1995.
Mizushima et al., Nucleic Acid Res. 18, 5322, 1990.
Knudsen et al., Exp. Cell. Res., 188, 175-184, 1990.
Mege et al., J. Cell. Sci., 103, 897-906, 1992.
Donalies et al., Pro. Natl. Acad., Sci, 88, 8024-8028, 1991.
Rosen et al., Cell, 69, 1107-1119, 1992.
Smith, Donald B. et al., “Single-step purification of polypeptides expressed inEscherichia colias fusions with glutathione S-transferase”, Gene, 67, (1998) pp. 31-40.
T. Yagami-Hiromasa et al., “Meltrina, A Novel Metalloprotease-Disintegrin, Participates in Myotube Formation”, Cell Structure and Function, vol. 20 No. 6, 1995, p. 585, 2A-1345.
Kurizaki Tomohiro et al., “A Novel Cellular Adhesive Molecule Meltrin belonging to Metalloprotease Dysintegrain Family”, Experimental Medicine 14 (10), pp. 1352-1356, Jan. 7, 1996.
Endo, Tsuyoshi, “ADAM Family and Cell Fusion”, Biochemistry, vol. 68, No. 8, pp. 1453-1458, Aug. 1996.
Cho, Chunghee et al., “Chromosomal Assignment of Four Testis-Expressed Mouse Genes from a New Family of Transmembrane Proteins (ADAMs) Involved in Cell-Cell Adhesion and Fusion”, Genomics, 34, Apr. 10, 1996, pp. 413-417.
J. Fujisawa et al., “Molecular Mechanism of Differentiation and Formation of Skeletal Muscle”Generalized Research Report in Fiscal Years Heisei 5 to 7, Morphological and Biochemical and Molecular Biological Basic Research on Muscular Dystrophy, Mar. 1996, pp. 85-88.
Morrison, T. G., “Structure, function, and introcellular processing of paramyxovirus membrane proteins”, Virus Research, 10 (1988), pp. 113-136.
Blobel, Carl P. et al., “A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion”, Nature, vol. 356, Mar. 19, 1992, pp. 248-252.
G. Weskamp et al., “A Family of Cellular Proteins Related to Snake Venom Disintegerins”, Proc. Natl. Acad. Sci. USA 91, 1994.
International Search Report in corresponding application No. PCT/JP96/03017 completed Jan. 16, 1997 and mailed Jan. 28, 1997.
T. Kurisaki et al., “Cloning of Meltrins, Novel Members of Metalloprotease-Disintegrin Family Involved in Myogenesis”, Cell Structure and Function, vol. 20 No. 6, 1995, p. 585, 2A-1330.
Seiler-Tuyns, Anne et al., Expression and Regulation of Chicken Actin Genes Introduced into Mouse Myogenic and Nonmyogenic Cells, Proceedings of the National Academy of Sciences, May 15, 1984, vol. 81, No. 10, 2980-2984.
Kurisaki et al., “Cloning of novel members of metalloprotease-disintegrin family which are involved in myotube formation”, 2A-1330 Abstract of the 48th Annual Meeting of the Japan Societ for Cell Biology, 1995.
Yagami et al., “Function analysis of meltrin genes which participate in myogenesis”, 2A-1345 Abstract of the 48th Annual Meeting of the Japan Society for Cell Biology, 1995.
Fujisawa Atsuko
Ogawa Naoki
Orii Chitose
Shirakawa Kamon
Yamakawa Toru
Birch & Stewart Kolasch & Birch, LLP
Haddad Maher M
Mochida Pharmaceutical Co. Ltd.
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