Melt granulated compositions for preparing sustained release dos

Details Melt granulated compositions for preparing sustained release dos Melt granulated compositions for preparing sustained release dos

1992-03-31

1995-04-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424480, 424498, 424488, A61K 914

Patent

active

054035937

ABSTRACT:
Therapeutically active sustained release dosage forms are described which are prepared from compositions which comprise (A) a hydrophilic cellulose ether polymer or mixtures thereof as a binder matrix material, (B) a granulating medium selected from the group consisting of a lipid component, polyethylene glycol polymers, and mixtures thereof, said granulating medium having a melting range higher than about 30.degree. C., and (C) a therapeutically active medicament, said components being in melt association. The compositions are prepared by a melt granulation process.

REFERENCES:
patent: 3147187 (1964-09-01), Playfair
patent: 3870790 (1975-03-01), Lowey
patent: 4140755 (1979-02-01), Sheth et al.
patent: 4389393 (1983-06-01), Schor
patent: 4774074 (1988-09-01), Snipes
patent: 4828836 (1989-05-01), Elger
patent: 4849229 (1989-07-01), Gaylord et al.
patent: 4882167 (1989-11-01), Jang
patent: 5023108 (1991-06-01), Bagaria
Pharmaceutical Dosage Forms: Tablets, vol. 1 (2nd Ed.) ed. by Lieberman et al., Marcel Dekker Inc. (1989), p. 150.
Flanders, P. et al., The Control of Drug Release from Conventional Melt Granulation Matrices, Drug Devel. and Ind. Pharm., 13 (6), 1001-1022 (1987).
Kopcha, M. et al. Development and In-Vitro Characterization of Sustained -Release Acetaminophen Tablets, Phar. Res., 4, Suppl S27 (1987).
McTaggart et al., "The evaluation of formulation and processing conditions of a melt granulation process," International Journal of Pharmaceutics, 19 (1984) 139-148.
Pataki et al., "Rolling Bed Granulation With Local Melt Forming, " Proc. Conf. Appl. Chem. Unit Oper. Processes, 3(4):258-270 (1983).
Rubinstein et al., Drug Development and Industrial Pharmacy, 6(5), 451-473 (1980).
G Shah, et al., "Polyethylene Glycol as a Binder for Tablets," Journal of Pharmaceutical Sciences 66, No. 11, Nov. 1977, 1551-1552.
Rubinstein, M., "A New Granulation Method for Compressed Tablets," Pharm. Pharmac., 28, Suppl. 67P (1976).

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