MELKS as modifiers of the Rac pathway and methods of use

Details MELKS as modifiers of the Rac pathway and methods of use MELKS as modifiers of the Rac pathway and methods of use

2004-08-12

2011-11-29

Cheu, Jacob (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200, C435S007910, C436S518000

Reexamination Certificate

active

08067181

ABSTRACT:
Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.

REFERENCES:
patent: 2003/0198972 (2003-10-01), Erlander et al.
Heyer et al., “Expression ofMelk, a New Protein Kinase, During Early Mouse Development,”Developmental Dynamics, 215:344-351 (1999).
Heyer et al., “New Member of the Snf1/AMPK Kinase Family,Melk, Is Expressed in the Mouse Egg and Preimplantation Embryo,”Molecular Reproduction and Development, 47:148-156 (1997).
International Search Report for PCT/US04/26231 mailed May 23, 2005.
Vulsteke et al., “Inhibition of Spliceosome Assembly by the Cell Cycle-regulated Protein Kinase MELK and Involvement of Splicing Factor NIPP1,”The Journal of Biological Chemistry, 279(10):8642-8647 (2004).
Heyer, B.S. et al.: “Expression of MELK, a New Protein Kinase, During Early Mouse Development,” Developmental DynamicsWiley-Liss, Inc., New York, NY, US, vol. 215, No. 4, Aug. 1999, pp. 344-351.
Heyer, B.S., et al.: “New Member of the SNF1/AMPK Kinase Family, MELK, Is Expressed in the Mouse Egg and Preimplantation Embryo,” Molecular Reproduction and Development, LISS, New York, NY, US, vol. 47, No. 2, 1997, pp. 148-156.

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