Melatonin derivatives and anti-free-radical dermocosmetics compr

Details Melatonin derivatives and anti-free-radical dermocosmetics compr Melatonin derivatives and anti-free-radical dermocosmetics compr

1997-07-25

2000-07-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 59, 424 701, 424 705, 514415, 548504, A61K 600, C07D20916

Patent

active

060934093

ABSTRACT:
Topically applicable dermocosmetic compositions for combating the clinical signs of skin aging and/or for improving the appearance of the skin, the scalp or the hair, comprise an anti-free-radical effective amount of at least one novel melatonin derivative having the structural formula (I): ##STR1## in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, with the proviso that the hydroxyl radical is in the 4-, 6- or 7-position on the indole ring system, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.

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Brazilian J. Med. Biol. Res., vol. 26, No. 11, 1993, pp. 1141-1155.
Ann. N.Y. Acad. Sci., vol. 786, 1996, pp. 362-378.
Neurosci. Biobehav. Rev., vol. 17, No. 3, 1993, pp. 347-357.
Adv. Exp. Med. Biol., vol. 3398, 1996, pp. 307-313.
Advances in Pineal Research, vol. 7, 1994, pp. 211-228.

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