Melatonin derivative dermocosmetic compositions for whitening/de

Details Melatonin derivative dermocosmetic compositions for whitening/de Melatonin derivative dermocosmetic compositions for whitening/de

1997-07-25

1999-08-03

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 62, 424401, 424489, 514844, 514845, 514937, 514944, A01N 4338, A61K 31405, A61K 7135, A61K 700

Patent

active

059326085

ABSTRACT:
Topically applicable dermocosmetic compositions for whitening/depigmenting human skin, comprise a skin-whitening/depigmenting effective amount of at least one melatonin derivative having the structural formula (I): in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, with the proviso that the hydroxyl radical is in the 4-, 6- or 7-position on the indole ring system, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.

REFERENCES:
patent: 4746674 (1988-05-01), Pierpaoli et al.
Patent Abstract of Japan, vol. 011, No. 060 (C-405), Feb. 24, 1987 & JP 61 221104 A.
Chemical Abstracts, vol. 82, No. 5, Feb. 5, 1975, Columbus, Ohio, abstract No. 28987.
Chemical Abstracts, vol. 85, No. 1, Jul. 5, 1976, Columbus, Ohio, abstract No. 590.
Bangha et al., "Topical melatonin (N-acetyl-5-methoxytryptamine) suppresses UV-induced erythema", The Journal of Investigative Dermatology, V106, No. 4, p. 944, Abstract No. 833, Apr. 1996.
Nordlund et al., "The effects of oral melatonin on skin color and on the release of pituitary hormones", J. Clin. Endocrinol. Metab. 45, 768-774, 1977.
Sugden, "Aggregation of pigment granules in single cultured Xenopus laevis melanophored by melatonin analogues", Br. J. Pharmacol., 104, 922-927, 1991.
Valverde et al., "Melatonin antagonizes alfa-melanocyte-stimulating hormone enhancement of melanogenesis in mouse melanoma cells by blocking the hormone-induced accumulation of a c locus typrosinase", Eur. J. Biochem., 232, 257-263, 1995.

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