Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase – Separation of immune complex from unbound antigen or antibody
Patent
1983-04-01
1985-12-31
Wiseman, Thomas G.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
Separation of immune complex from unbound antigen or antibody
260112R, 424 11, 424 85, 424 88, 435 4, 435 7, 435948, 436518, 436536, 436542, 436543, 436804, 436813, 436815, 436823, G01N 3354, A61K 39395, A61K 3944, A61K 4300
Patent
active
045621608
ABSTRACT:
The present invention concerns novel immunoprecipitating autologous antibodies which recognize the Class 1 gp90 antigen on melanoma cells. These antibodies, optionally tagged with a chromophoric or radioactive label and immobilized on an inert support, may be used to recognize and isolate the gp90 antigen from melanoma cell extracts. Monoclonal antibodies to melanoma may be screened with the gp90 antigen for those which recognize epitopes other than the FD antigenic system.
The cell line containing the gp90 antigen which has been cultured in vitro is a source of gp90 antigen for generation of monoclonal antibodies which will be useful in analyzing the gp90 antigen for those epitopes which may be of diagnostic value in immunoassay of melanoma.
REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4361544 (1982-11-01), Goldenberg
Loop, S. M. et al., Int. J. Cancer, vol. 27, pp. 775-781 (1981).
Natali, P. G. et al., J. National Cancer Institute, vol. 67(3), pp. 591-601 (1981).
Steplewski, Z. et al., Cancer Research, vol. 41, pp. 2723-2727 (1981).
Seeger, R. C. et al., Cancer Research, vol. 41, pp. 2714-2717 (1981).
Bumol, T. F. et al., Hybridoma, vol. 1, pp. 283-292 (1-1982).
Yeh, M. Y. et al., International J. of Cancer, vol. 29, pp. 269-275 (1982).
Houghton, A. N. et al., J. Experimental Medicine, vol. 156(6), pp. 1755-1766 (1982).
Reisfeld, R. A. et al., Nature, vol. 298, pp. 325-326 (1982).
Pukel C. S. et al., J. Experimental Medicine, vol. 155, pp. 1133-1147 (4-1982).
Johnson, J. P. et al., European J. Immunology, vol. 11, pp. 825-831 (1981).
Morgan, A. C. et al., Hybridoma, vol. 1, pp. 27-36 (1981).
Wilson, B. S. et al., Int. J. Cancer, vol. 28, pp. 293-300 (1981).
Brown, J. P. et al., Proc. Natl. Acad. Sci. USA, vol. 78, pp. 539-543 (1981).
Mitchell, K. F. et al., Proc. Natl. Acad. Sci. USA, vol. 77, pp. 7287-7291 (1980).
Dippold, W. G. et al., Proc. Natl. Acad. Sci. USA, vol. 77, pp. 6114-6118 (1980).
Carrel, S. et al., Cancer Research, vol. 40, pp. 2523-2528 (1980).
Brown, J. P. et al., J. Biological Chemistry, vol. 255(11), pp. 4980-4983 (1980).
Floyd, K. O. et al., J. National Cancer Institute, vol. 63(3), pp. 623-634 (1979).
Ueda, R. et al., J. Experimental Medicine, vol. 150, pp. 564-579 (1979).
Carey, T. E. et al., Proc. Natl. Acad. Sci., USA, vol. 76(6), pp. 2898-2902 (1979).
Pfreundschuh, M. et al., Proc. Natl. Acad. Sci., USA, vol. 75(10), pp. 5122-5126 (1978).
Koprowski, H. et al., Proc. Natl. Acad. Sci. USA, vol. 75(7), pp. 3405-3409 (1978).
Houghton Alan N.
Livingston Philip O.
Lloyd Kenneth O.
Mattes M. Jules
Oettgen Herbert F.
Moskowitz M.
Sloan-Kettering Institute
Wiseman Thomas G.
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