Melanoma differentiation associated gene-5 and promoter and...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S024100, C514S04400A

Reexamination Certificate

active

10228897

ABSTRACT:
The invention provides for an isolated nucleic acid encoding Mda-5 (melanoma differentiation associated gene-5) and an isolated Mda-5 polypeptide. The invention further provides a vector comprising the nucleic acid encoding Mda-5, as well as a host cell comprising the vector. The invention provides an antibody which specifically binds to an Mda-5 polypeptide. The invention further provides a method for determining whether a compound is an inducer of Mda-5 gene expression and assays to determine whether a compound modifies the enzymatic activity of the Mda-5 polypeptide.

REFERENCES:
patent: 3952097 (1976-04-01), Levy
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5643761 (1997-07-01), Fisher et al.
patent: 5912236 (1999-06-01), Xu et al.
patent: 6025127 (2000-02-01), Sidransky
patent: 6051376 (2000-04-01), Fisher et al.
patent: 6207145 (2001-03-01), Tovey
patent: 2002/0048763 (2002-04-01), Penn et al.
patent: 336523 (1989-10-01), None
patent: WO 90/11092 (1990-10-01), None
patent: WO 93/23034 (1993-11-01), None
patent: WO 95/11986 (1995-05-01), None
patent: WO 01/85955 (2001-11-01), None
Accession No. AQ284992, and corresponding Homology Comparison RESULT #1.
Ikeda et al. Nucleic Acids Research 20: 2517-2524, 1992.
Nagano et al. Arterioscler. Thromb. Vasc. Biol. 21: 985-990, 2001.
Kang DC, Gopalkrishnan RV, Jiang H, Wu Q, Fisher PB (2000). Melanoma differentiation associated gene 5 (MDA-5): a novel interferon-inducible putative RNA helicase involved in cell survival. Proceedings of the American Association for Cancer Research 41:509-510.
Brenner SE (1999). Errors in genome annotation. TIG 15(4):132-133.
Huang F, Adelman J, Jiang H, Goldstein NI, Fisher PB (1999a). Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene 18:3546-3552.
Huang F, Adelman J, Jiang H, Goldstein NI, Fisher PB (1999b). Differentiation induction subtraction hybridization (DISH): a strategy for cloning genes displaying differential expression during growth arrest and terminal differentiation. Gene 236:125-131.
Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (1999). The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat. Genet. 21:440-443.
Doerks T, Bairoch A, Bork P (1998). Protein annotation: detective work for function prediction. TIG 14(6):248-250.
Lin JJ, Jiang H, Fisher PB (1998). Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene. Gene 207(2):105-110.
Lüking A, Stahl U, Schmidt U (1998). The protein family of RNA helicases. Crit. Rev. Biochem. Mol. Biol. 33(4):259-296.
Hofmann K, Bucher P, Tschopp J (1997). The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22(5):155-156.
Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (1996). Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J. Biol. Chem. 271(37):22878-22884.
Su ZZ, Shi Y, Fisher PB (1997). Subtraction hybridization identifies a progression elevated gene PEG-3 with sequence homology to a growth arrest and DNA damage inducible gene. Proc. Natl. Acad. Sci. USA 94:9125-9130.
Jiang H, Lin J, Su ZZ, Fisher PB (1996a). The melanoma differentiation associated gene-6 (mda-6), which encodes the cyclin-dependent kinase inhibitor p21, may function as a negative regulator of human melanoma growth and progression. Mol. Cell. Different. 4:67-89.
Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CSH, Fisher PB (1996b). The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc. Natl. Acad. Sci. USA 93:9160-9165.
Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB (1995a). Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth, and progression. Oncogene 11: 2477-2486.
Jiang H, Lin J, Su ZZ, Herlyn M, Kerbel RS, Weissman BE, Welch DR, Fisher PB (1995b). The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation, and progression in human melanoma cells. Oncogene 10:1855-1864.
Jiang H, Fisher PB (1993). Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells. Mol. Cell. Different. 1:285-299.
Jiang H, Su ZZ, Boyd J, Fisher PB 91993). Gene expression changes associated with reversible growth suppression and the induction of terminal differentiation in human melanoma cells. Mol. Cell. Different. 1:41-66.
Jiang H, Waxman S, Fisher PB (1993). Regulation of c-fos, c-junandjun-B gene expression in human melanoma cells induced to terminally differentiate. Mol. Cell. Different. 1:197-214.
Fisher PB, Grant S (1985). Effects of interferon on differentiation of normal and tumor cells. Pharmacol. Ther. 27(2):143-166.
Kawai T, et al. IPS-l, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. Oct. 2005;6(10):981-8. Epub Aug. 28, 2005.
Meylan E, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by Hepatitis C virus. Nature. 2005 437(7062):1167-72. Epub Sep. 21, 2005.
Kang DC, Gopalkrishnan RV, Lin L, Randolph A, Valerie K, Pestka S, Fisher PB. (2004) Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. Oncogene 23(9):1789-800.
Cocude C, et al. (2003) A novel Cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.J Gen Virol. 84(Pt 12):3215-25.
Garcia-Sastre, (2002) Mechanisms of inhibition of the host interferin alpha/beta-mediated antiviral responses by viruses. Microbes Infect. 4(6):647-55.
Kang et al., (2002) mda-5: An interferon-inducible putative RNA Helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Natl Acad Sci U S A. 99(2):637-42.
Kovacsovics M, et al. Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr Biol. May 14, 2002;12(10):838-43. Erratum in Curr Biol. Sep.17, 2002;12(18):1633.
Nagano M, et al. (2001) Point mutation (-69 G-->A) in the promoter region of cholesteryl ester transfer protein gene in Japanese Hyperalphalipoproteinemic subjects. Arterioscler Thromb Vasc Biol. Jun.;21(6):985-90.
Herbein and O'Brein (2000) Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. Proc Soc Exp Biol Med., 223(3):241-57.
Brenner SE (1999). Errors in genome annotation. TIG 15(4):132-133.
Huang F, Adelman J, Jiang H, Goldstein NI, Fisher PB (1999a). Indenification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene 18:3546-3552.
Huang F, Adelman J, Jiang H, Goldstein NI, Fisher PB (1999b). Differentiation induction subtraction hybridization (DISH): a strategy for cloning genes displaying differential expression during growth and terminal differentiation. Gene 236:125-131.
Sibson et al., (1999) Sequence 240 from Patent EP0587279 GenBank Accession Number A77533 377 bp DNA.
Sibson et al., (1999) Sequence 240 from Patent WO9401548 GenBank Accession Number GA74554 377 bp, DNA.
Adams MD (1998). Accession Number AQ284992, and correspnding Homology Comparison RESULT #1.
Bult CJ et al. (1998). Putatve ATP-dependent RNA helicase MJ1505, SwissProt Acc. No, Q58900.
Hofman K, Bucher P, Tschopp J (1997). The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22(5):155-156.
Jiang H. Su ZZ, Lin JJ, Goldstein NI, Young CSH, Fisher PB (1996b). The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc. Natl. Acad. Sci. USA 93:9160-9165.
Wood V et al. (1996). Putative helicase C188.13c. SwissProt Acc. No. Q09884.

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