Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-06-12
2007-06-12
Qian, Celine (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C536S023100
Reexamination Certificate
active
09515363
ABSTRACT:
The invention provides for isolated nucleic acids encoding an Mda-5 polypeptide as shown in SEQ ID NO:1. The invention also provides for isolated nucleic acids comprising derivatives of the sequence of SEQ ID NO:1 that encode polypeptides functionally equivalent to Mda-5. The invention further provides for fragments of the isolated nucleic acid of SEQ ID NO:1 that encode polypeptides having Mda-5 biological activity. Vectors comprising these isolated nucleic acids and host cells comprising these vectors are also provided by the instant invention.
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Huang et al., (1999) Differentiation induction subtraction hybridization (DISH): a strategy for cloning genes displaying differential expression during growth arrest and terminal differentiation. Gene 236:125-131.
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Lüking A, Stahl U, Schmidt U (1998) The protein family of RNA helicases. Crit. Rev. Biochem. Mol. Biol. 33(4):259-296.
Hofmann K, Bucher P, Tschopp J (1997) The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22(5):155-156.
Su ZZ, Shi Y, Fisher PB (1997) Subtraction hybridization identifies a progression elevated gene PEG-3 with sequence homology to a growth arrest and DNA damage inducible gene. Proc. Natl. Acad. Sci. USA 94:9125-9130.
Jiang H, Lin J, Su ZZ, Fisher PB (1996) The melanoma differentiation associated gene-6 (mda-6), which encodes the cyclin-dependent kinase inhibitor p21, may function as a negative regulator of human melanoma growth and progression. Mol. Cell. Different. 4:67-89.
Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CSH, Fisher PB (1996) The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc. Natl. Acad. Sci. USA 93:9160-9165.
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Fisher Paul B.
Gopalkrishnan Rahul V.
Kang Dong-Chul
Baker & Botts LLP
Qian Celine
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