Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-10-31
2010-06-29
Huff, Sheela J (Department: 1643)
Chemistry: molecular biology and microbiology
Vector, per se
C536S023100
Reexamination Certificate
active
07745212
ABSTRACT:
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.
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Kawakami Yutaka
Rosenberg Steven A.
Huff Sheela J
Leydig & Voit & Mayer
The United States of America as represented by the Department of
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