Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-08-01
2006-08-01
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07084111
ABSTRACT:
The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.
REFERENCES:
patent: 6127381 (2000-10-01), Basu et al.
patent: 6451783 (2002-09-01), Hadcock et al.
patent: WO 99/21571 (1999-05-01), None
patent: WO 99/54358 (1999-10-01), None
patent: WO 01/74844 (2001-10-01), None
patent: WO 02/18437 (2002-03-01), None
patent: WO 03/006620 (2003-01-01), None
Tota, et al., Biochemitry, 1999, 38, 897-904.
Han, G., J.M. quillan, K. Carlson, W. Sadee, V.J. Hruby (Feb. 27, 2003) “Design of Novel Chi8meric Melanotropin-Deltrophin Analogues. Discovery of the First Potent Human Melanocortin 1 Receptor Antagonist”J. Med. Chem. 46:810-819.
Joseph, Christine G., Andrzej Wilczynski, Jerry R. Holder, Zhimin Xiang, Rayna M. Bauzo, Joseph W. Scott, Carrie Haskell-Luevano (Dec. 2003) “Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity”Peptides24(12):1899-1908.
Szardenings, Michael et al. (Oct. 31, 1997) “Phage Display Selection on Whole Cells Yields a Peptide Specific for Melanocortin Receptor 1”Journal of Biological Chemistry272(44):27943-27948.
Wilczynski, Andrzej, Xiang S. Wang, Christine G. Joseph et al. (Apr. 22, 2004) “Identification of Putative Agouti-Related Protein (87-132)-Melanocortin-4 Receptor Interactions by Homology Molecular Modeling and Validation Using Chimeric Peptide Ligands”J. Med. Chem. 47(9):2194-2207.
Bolin, K.A. et al. “NMR Structure of Minimized Human Agouti Related Protein Prepared by Total Chemical Synthesis”FEBS Letters1999, pp. 125-131, vol. 451.
Castrucci, A.M.L. et al. “α-Melanotropin: The Minimal Active Sequence in the Lizard Skin Bioassay”General and Comparitive Endocrinology, 1989, pp. 157-163, vol. 73.
Hruby, V.J. et al., “α-Melanotropin: The Minimal Active Sequence in the Frog Skin Bioassay”J. Med. Chem., 1987, pp. 2126-2130, vol. 30.
Holder, J. R. et al. “Structure-Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH2at the Mouse Melanocortin Receptors. 1. Modifications at the His Position”J. Med. Chem., 2002, pp. 2801-2810, vol. 45.
Holder, J. R. et al., “Structure-Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH2at the Mouse Melanocortin Receptors: Part 2 Modifications at the Phe Position”J. Med. Chem., 2002, pp. 3073-3081, vol. 45.
Jackson, P. J. et al. “Design, Pharmacology, and NMR Structure of a Minimized Cystine Knot with Agouti-Related Protein Activity”Biochemistry, 2002, pp. 7565-7572, vol. 41. No. 24.
Kavarana, M. J. et al. “Novel Cyclic Templates of α-MSH Give Highly Selective and Potent Antagonists/Agonists for Human Melanocortin-3/4 Receptors”J. Med. Chem., 2002, pp. 2644-2650, vol. 45.
Kiefer, L. L. et al. “Melanocortin Receptor Binding Determinants in the Agouti Protein”Biochemistry, 1998, pp. 991-997, vol. 37.
Kiefer, L. L. et al. “Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors”Biochemistry, 1997, pp. 2084-2090, vol. 36.
Kim et al., “Hypothalamic Localization of thr Feeding Effect of Agouti-Related Peptide and α-Melanocyte-Stimulating Hormone,”Diabetes, Feb. 2000, pp. 177-182, vol. 49.
Haskell-Luevano, C. et al., “Characterization of Melanocortin NDP-MSH Agonist Fragments at the Mouse Central and Peripheral Melanocortin Receptors”J. Med. Chem., 2001, pp. 2247-2252, vol. 44.
Haskell-Luevano, C. et al. “The Agouti-Related Protein Decapeptide (Yc[CRFFNAFC]Y) Possesses Agonist Activity at the Murine Melanocortin-1 Receptor”Peptides, 2000, pp. 683-689, vol. 21.
Haskell-Luevano, C. et al. “Structure Activity Studies of the Melanocortin-4 Receptor byin VitroMutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants”Biochemistry, 2001, pp. 6164-6179, vol. 40.
McNulty, J. C. et al. “High-Resolution NMR Structure of the Chemically-Synthesized Melanocortin Receptor Binding Domain AGRP(87-132) of the Agouti-Related Protein”Biochemistry, 2001, pp. 15520-15527, vol. 40.
Al-Obeidi, F. et al. “Potent and Prolonged Acting Cyclic Lactam Analogues of α-Melanotropin: Design Based on Molecular Dynamics”J. Med. Chem. 1989, pp. 2555-2561, vol. 32.
Oosterom, J. et al. “Common Requirements for Melanocortin-4 Receptor Selectivity Unrelated Melanocortin Agonist and Endogenous Antagonist, Agouti Protein”The Journal of Biological Chemistry, Jan. 12, 2001, pp. 931-936, vol. 276, No. 2.
Perry, W. L. et al., “A Transgenic Mouse Assay for Agouti Protein Activity”Genetics, May 1995, pp. 267-274, vol. 140.
Perry, W. L. et al. “Coupled Site-Directed Mutagenesis/Transgenesis Identifies Important Functional Domains of the Mouse Agouti Protein”Genetics, Sep. 1996, pp. 255-264, vol. 144.
Quillan, J. M. et al. “A Synthetic Human Agouti-Related Protein-(83-132)-NH2Fragment is a Potent Inhibitor of Melanocortin Receptor Function”FEBS Letters, 1998, pp. 59-62, vol. 428.
Sawyer, T. K. et al. “4- Norleucine, 7-D-Phenylalanine-$\Alpha $-Melanocyte-Stimulating Hormone: A Highly Potent -$\Alpha $-Melanotropin with Ultralong Biological Activity”Biochemistry, Oct. 1980, pp. 5754-5758, vol. 77, No. 10.
Tota, M. R. et al. “Molecualr Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Recptors”Biochemistry, 1999, pp. 897-904, vol. 38.
Willard, D. H.et al. “Agouti Structure and Function: Characterization of a Potent α-Melanocyte Stimulating Hormone Receptor Antagonist”Biochemistry, 1995, pp. 12341-12346, vol. 34.
Yang, Y-K. et al. “Functional Properties of an Agouti Signaling Protein Variant and Characteristics of its Cognate Radioligand”Am. J. Physiol Regulatory Integrative Comp. Physiol., 2001, pp. R1877-R1886, vol. 281.
Yang, Y-K. et al. “Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor”Biochemistry, 2000, pp. 14900-14911, vol. 39.
Yang, Y-K. et al. “Characterization of Agouti-Related Protein Binding to Melanocortin Receptors”Molecular Endocrinology, 1999, pp. 148-155.
Campell Bruce R.
Gudibande Satyanarayana R.
Saliwanchik Lloyd & Saliwanchik
University of Florida Research Foundation Inc.
LandOfFree
Melanocortin receptor templates, peptides, and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Melanocortin receptor templates, peptides, and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanocortin receptor templates, peptides, and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3667137