Melanocortin receptor ligands

Details Melanocortin receptor ligands Melanocortin receptor ligands

2006-07-10

2011-10-18

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S021100, C514S021700, C530S317000, C530S328000

Reexamination Certificate

active

08039435

ABSTRACT:
The present invention is directed to compounds according to formula,in-line-formulae description="In-line Formulae" end="lead"?(R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1,in-line-formulae description="In-line Formulae" end="tail"?and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.

REFERENCES:
patent: 6127381 (2000-10-01), Basu et al.
patent: 6350430 (2002-02-01), Dooley et al.
patent: 6613874 (2003-09-01), Mazur et al.
patent: 6951916 (2005-10-01), Mazur et al.
patent: 2003/0113263 (2003-06-01), Marks et al.
patent: 2003/0212002 (2003-11-01), Haskell-Luevano et al.
patent: 2004/0138136 (2004-07-01), Sharma et al.
patent: 2004/0260063 (2004-12-01), Haskell-Luevano
patent: 2007/0123453 (2007-05-01), Heiman et al.
patent: 98/37097 (1998-08-01), None
patent: 2005/000338 (2005-01-01), None
patent: WO 2005000338 (2005-01-01), None
patent: 2005/019184 (2005-03-01), None
patent: 2005/019212 (2005-03-01), None
patent: 2005/000339 (2005-06-01), None
patent: 2005/054279 (2005-06-01), None
patent: 2006/037188 (2006-04-01), None
patent: 2006/073771 (2006-07-01), None
patent: 2006/073772 (2006-07-01), None
patent: 2007/022774 (2007-03-01), None
patent: 2005/102377 (2010-11-01), None
Haskell-Luevano, “Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors”, J. Med. Chem, 1997, 40:1738-48.
Kask, “Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats”, Biochem. Biophys. Res. Comm., 1998, 245:90-3.
Navarro, “Effects of melanocortin receptor activation and blockade on ethanol intake: A possible role for the melanocortin-4 receptor”, Alcohol Clin. Exp. Res., 2005, 29:949-57.
Nikiforovich, “Studies of conformational isomerism in alpha-melanocyte stimulating hormone by design of cyclic analogues”, Biopolymers, 1998, 46:155-67.
Wilczynski, A. et al., “Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[β-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2peptide template”, J. Med. Chem., 2005, 48:3060-3075.
Hruby, V. J. et al., “Design of potent and specific melanotropin agonists and antagonists: investigating ligands for new receptors”, Peptides, 1996, p. 485-486.
Hruby, V. J. et al., “Designing potent and selective melanotropin agonist and antagonist ligands for the recently discovered melanocortin 3, 4 and 5 receptors”, Peptides, 1998, p. 70-71.
Mayer, J. P. et al., “Discovery of a B-MSH-derived MC-4R selective agonist”, J. Med. Chem., 2005, 48:3095-3098.
Yan, L. Z. et al., “Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold”, Bioorganic & Medicinal Chem. Lett., 15:4611-4614, (Oct. 15, 2005).

Affiliated with

Also associated with

Rating

Melanocortin receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Melanocortin receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanocortin receptor ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4286516