Melanocortin receptor ligands

Details Melanocortin receptor ligands Melanocortin receptor ligands

2006-08-08

2006-08-08

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S315000, C514S423000, C514S424000, C548S540000, C548S530000

Reexamination Certificate

active

07087759

ABSTRACT:
Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula:wherein A is a conformationally restricted ring system selected from the group consisting of:a) non-aromatic carbocyclic rings;b) aromatic carbocyclic rings;c) non-aromatic heterocyclic rings;d) aromatic heterocyclic rings;wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.

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