Melanocortin receptor ligands

Details Melanocortin receptor ligands Melanocortin receptor ligands

2006-11-07

2006-11-07

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S391000, C544S384000, C544S386000, C544S363000, C546S195000, C546S205000, C546S226000, C548S540000, C540S575000, C514S254010, C514S255010, C514S423000, C514S319000, C514S330000, C514S218000

Reexamination Certificate

active

07132539

ABSTRACT:
The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1alkyl units selected from the group consisting of C1–C12linear or branched alkyl, C3–C8cyclic alkyl, C2–C12linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula:wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7ais selected from the group consisting of hydrogen, —CO2H, —CONH2, —CONHCH3, and —CON(CH3)2; R8is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.

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