Melanocortin receptor agonists

Details Melanocortin receptor agonists Melanocortin receptor agonists

2009-11-10

2011-10-18

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S238000, C544S364000, C514S252020, C514S253090, C514S254010

Reexamination Certificate

active

08039622

ABSTRACT:
The present invention relates to a compound having a good agonistic activity to melanocortin receptor, or pharmaceutically acceptable salt or isomer thereof, and an agonistic composition for melanocortin receptor comprising the same as an active ingredient.

REFERENCES:
patent: 6534503 (2003-03-01), Dines et al.
patent: 2003/0236262 (2003-12-01), Bakshi et al.
patent: 2004/0019094 (2004-01-01), Lundstedt et al.
patent: 2007/0129346 (2007-06-01), Lee et al.
patent: 2007-131570 (2007-05-01), None
patent: WO 01/55109 (2001-08-01), None
patent: WO 01/70337 (2001-09-01), None
patent: WO 01/70708 (2001-09-01), None
patent: WO 02/15909 (2002-02-01), None
patent: WO 02/18327 (2002-03-01), None
patent: WO 02/059095 (2002-08-01), None
patent: WO 02/059107 (2002-08-01), None
patent: WO 02/059108 (2002-08-01), None
patent: WO 02/059117 (2002-08-01), None
patent: 02/067869 (2002-09-01), None
patent: 02/068387 (2002-09-01), None
patent: 02/068388 (2002-09-01), None
patent: WO 02/081443 (2002-10-01), None
patent: WO 02/085925 (2002-10-01), None
patent: WO 03/009847 (2003-02-01), None
patent: WO 03/009850 (2003-02-01), None
patent: WO 2004/078716 (2004-09-01), None
patent: WO 2004/078717 (2004-09-01), None
patent: WO 2004/087159 (2004-10-01), None
patent: WO 2005/040109 (2005-05-01), None
patent: WO 2005/047251 (2005-05-01), None
patent: WO 2005/077935 (2005-08-01), None
patent: WO 2006/019787 (2006-02-01), None
patent: WO 2006/020277 (2006-02-01), None
patent: WO 2006/072393 (2006-07-01), None
patent: WO 2007/015157 (2007-02-01), None
patent: WO 2007/015162 (2007-02-01), None
patent: WO 2007/041052 (2007-04-01), None
patent: WO 2007/041061 (2007-04-01), None
patent: WO 2007/047496 (2007-04-01), None
patent: WO 2007/096186 (2007-08-01), None
patent: WO 2007/096763 (2007-08-01), None
patent: WO 2007/141343 (2007-12-01), None
patent: WO 2008/007930 (2008-01-01), None
patent: WO 2008/039418 (2008-04-01), None
Bakshi et al., “1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the Synthesis of Potent Human Melanocortin-4 Receptor Selective Agonists”, Bioorganic & Medicinal Chemistry Letters, vol. 15, 2005, pp. 3430-3433, Elsevier Ltd.
Greene et al., “Protection for the Amino Group”, Protective Groups in Organic Synthesis, 1991, pp. 309-405, Chapter 7, John Wiley & Sons, Inc.
Herpin et al., “Discovery of Tyrosine-Based Potent and Selective Melanocortin-1 Receptor Small-Molecule Agonists with Anti-Inflammatory Properties”, J. Med. Chem., 2003, vol. 46, pp. 1123-1126, American Chemical Society.
Palucki et al., “Discovery of (2S)-N[(1R)-2-[4-cyclohexyl-4[[(1,1-dimethylethyl)-amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a Potent and Selective Melanocortin Subtype-4 Receptor Agonist”, Bioorganic & Medicinal Chemistry, vol. 15, pp. 171-175, 2005, Elsevier Ltd.
Sebhat et al., “Design and Pharmacology of N-[3R]-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-1H-1,2,4-triazol-1-ylmethyl)piperdin-1-yl]-2oxoethylamine(1), a Potent Selective Melanocortin Subtype-4 Receptor Agonist”, Journal of Medicinal Chemistry, Oct. 10, 2002, pp. 4589-4593, vol. 45, No. 21, American Chemical Society.
Ye et al., “Discovery and Activity of (1,R,4S,6R)-N-[1R-2[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[4-fluorophenyl)methyl]-1-oxoethyl]-2-methyl-2-azabicyclo-[2.2.2]octane-6-carboxamide (3, RY764), a Potent and Selective Melanocortin Subtype-4 Receptor Agonist”, Bioorganic & Medicinal Chemistry Letters, vol. 15, 2005, pp. 3501-3505, Elsevier Ltd.

Affiliated with

Also associated with

Rating

Melanocortin receptor agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Melanocortin receptor agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanocortin receptor agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4293908