Melanocortin 1 receptor selective compounds

Details Melanocortin 1 receptor selective compounds Melanocortin 1 receptor selective compounds

2005-12-29

2010-02-16

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S014800, C514S015800

Reexamination Certificate

active

07662782

ABSTRACT:
The invention relates to methods of treatment comprising administering a compound of the general formula (1):to a patient or a healthy individual.

REFERENCES:
patent: 4288627 (1981-09-01), Kubicek
patent: 5731408 (1998-03-01), Hadley et al.
patent: 2009/0069242 (2009-03-01), Jonassen
patent: 91 17243 (1991-11-01), None
patent: 9511988 (1995-05-01), None
patent: 9946283 (1999-09-01), None
patent: 99 57148 (1999-11-01), None
patent: 01 04156 (2001-01-01), None
patent: 01 36980 (2001-05-01), None
patent: 01 90140 (2001-11-01), None
Bagutti, C. et al., “[111In]-DTPA-Labeled Analogues of α-Melanocyte-Stimulating Hormone for Melanoma Targeting: Receptor Binding In Vitro and In Vivo,”Int. J. Cancer 58:749-755, Wiley-Liss, Inc. (1994).
Bhardwaj, R.S. et al., “Pro-Opiomelanocortin-Derived Peptides Induce IL-10 Production in Human Monocytes,”J. Immunol. 156:2517-2521, The American Association of Immunologists (1996).
Cone, R.D. et al., “The Melanocortin Receptors: Agonists, Antagonists, and the Hormonal Control of Pigmentation,”Recent Prog. Horm. Res. 51:287-317, The Endocrine Society (1996).
De Wied, D. and Jolles, J., “Neuropeptides Derived From Pro-Opiocortin: Behavioral, Physiological, and Neurochemical Effects,”Physiol. Rev. 62:976-1059, The American Physiological Society (1982).
Eberle, A.N., “Structure-Activity Relationships of the Melanotropins,” inThe Melanotropins: Chemistry, Physiology and Mechanisms of Action, Eberle, A.N., Ed., S. Karger Publishing, Basel, Switzerland, pp. 333-379 (1988).
Gonindard, C. et al., “The Administration of an α-MSH Analogue Reduces the Serum Release of IL-1α and TNFα Induced by the Injection of a Sublethal Dose of Lipopolysaccharides in the BALB/c Mouse,”Pigment Cell Res. 9:148-153, Munksgaard (1996).
Gruber, K.A. and Callahan, M.F., “ACTH-(4-10) through γ-MSH: evidence for a new class of central autonomic nervous system-regulating peptides,”Am. J. Physiol. 257:R681-R694, The American Physiological Society (1989).
Hartmeyer, M. et al., “Human Dermal Microvascular Endothelial Cells Express the Melanocortin Receptor Type 1 and Produce Increased Levels of IL-8 upon Stimulation with α-Melanocyte-Stimulating Hormone,”J. Immunol. 159:1930-1937, The American Association of Immunologists (Aug. 1997).
Hnatowich, M.R. et al., “ACTH receptors in nervous tissue. High affinity binding-sequestration of [125I] [Phe2,Nle4]ACTH 1-24 in homogenates and slices from rat brain,”Can. J. Physiol. Pharmacol. 67:568-576, National Research Council of Canada (1989).
Hol, E.M. et al., “Protection by an ACTH4-9Analogue Against the Toxic Effects of Cisplatin and Taxol on Sensory Neurons and Glial Cells In Vitro,”J. Neurosci. Res. 39:178-185, Wiley-Liss, Inc. (1994).
Hruby, V.J. et al., “Cyclic Lactam α-Melanotropin Analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] α-Melanocyte-Stimulating Hormone-(4-10)-NH2with Bulky Aromatic Amino Acids at Position 7 Show High Antagonist Potency and Selectivity at Specific Melanocortin Receptors,”J. Med. Chem. 38:3454-3461, American Chemical Society (1995).
Klein, M.C. et al., “Pressor and Cardioaccelerator Effects of Gamma MSH and Related Peptides,”Life Sci. 36:769-775, Pergamon Press (1985).
Knittel, J.J. et al., “Structure-Activity Studies of Highly Potent Cyclic [Cys4,Cys10]Melanotropin Analogues,”J. Med. Chem. 26:125-129, American Chemical Society (1983).
Lichtensteiger, W. et al., “Pre- and Postnatal Ontogeny of [125I]Nle4,D-Phe7-α-MSH Binding Sites in Rat Brain,”Ann. N.Y. Acad. Sci. 680:652-654, New York Academy of Sciences (1993).
Lin, S.-Y., et al. “A γ-Melanocyte Stimulating Hormone-like Peptide Causes Reflex Natriuresis After Acute Unilateral Nephrectomy,”Hypertension 10:619-627, American Heart Association (1987).
Murphy, J.R. et al., “Genetic construction, expression and melanoma-selective cytotoxicity of a diphtheria toxin-related α-melanocyte-stimulating hormone fusion protein,”Proc. Natl. Acad. Sci. USA 83:8258-8262, National Academy of Sciences (1986).
Prusis, P. et al., “A Three Dimensional Model for the Interaction of MSH with the Melanocortin-1 Receptor,”Biochem. Biophys. Res. Commun. 210:205-210, Academic Press, Inc. (1995).
Sawyer, T.K. et al., “4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: A highly potent α-melanotropin with ultralong biological activity,”Proc. Natl. Acad. Sci. USA 77:5754-5758, National Academy of Sciences (1980).
Sawyer, T.K. et al., “[half-Cys4,half-Cys10]-α-Melanocyte-stimulating hormone: A cyclic α-melanotropin exhibiting superagonist biological activity,”Proc. Natl. Acad. Sci. USA 79:1751-1755, National Academy of Sciences (1982).
Tatro, J.B. et al., “Interaction of an α-Melanocyte-stimulating Hormone-Diphtheria Toxin Fusion Protein with Melanotropin Receptors in Human Melanoma Metastases,”Canc. Res. 52:2545-2548, American Association for Cancer Research (1992).
Thielemans, K.M.M., “Immunotherapy with Bispecific Antibodies,”Verh. K. Acad. Geneeskd. Belg. 57:229-248, Paleis Der Academein (1995).
Wiegant, V.M. et al., “Intracerebroventricular ACTH Activates the Pituitary-Adrenal System:Dissociation from a Behavioral Response,”Life Sci. 25:1791-1796, Pergamon Press (1979).
Schiöth, H.B. et al., “Binding and cyclic and linear MSH core peptides to the melanocortin receptor subtypes,”European Journal of Pharmacology 319:369-373, Elsevier Science B.V. (Feb. 1997).
Szardenings, M. et al., “Phage Display Selection on Whole Cells Yields a Peptide Specific for Melanocortin Receptor 1,”J. Biol. Chem. 272: 27943-27948, The American Society for Biochemistry and Molecular Biology, Inc. (Oct. 1997).
Abstract of Larsen et at: “Structural inducing probes (SIP)—blow new hope into the general use of peptides as drugs”, Abstract from Peptides 2000, Proceedings of the European Peptide Symposium 26th.
Catania, A., Rajora, F., Capsoni, F., Minonzio, R.A., Star, and Lipton, J.M. “The Neuropeptide alpha-MSH Has Specific Receptors on Neutrophils and Reduces Chemotaxis in Vitro” Peptides 17: No. 4 675-679, 1996.
Ehrlich, “DNA cloning in bacilluas subtilis” 1978, Proc. Natl. Acad. Sci. USA 75 (1978) (3):1433).
Guo and Sherman, “3′-end-forming signals of yeast mRNA” 1995, Molecular and Cellular Biology 15:(2) 5983-5990.
Hartmeyer, M., Scholzen T., Becher E, Bhardwaj R.S., Schwarz T. and Luger LA., “Human Dermal Microvascular Endothelial Cells Express the Melanocortin Receptor Type 1 and Produce Increased Levels of IL-8 upon Stimulation with alpha-Melanocyte-Stimulating Hormone” J.Immunol., 159: (4)1930-1937, 1997.
Kullmann, W. 1987, “Proteases as Biocatalysts For The Synthesis of Model Peptides”, Enzymatic Peptide Synthesis, CRC Press, Boca Raton, Florida, Chapter 7, pp. 41-59.
Lipton, J.M and Catania, A. “Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH” Immunol. Today 18: (3) 140-145. 1997.
Liu et al., 1996., “Orthogonal Ligation of Unprotected Peptide Segments through Pseudoproline Formation for the Synthesis of HIV-1 Protease Analogs”, J. Am. Chem. Soc. 118:307-312.
Luger, T.A., Scholzen T. and Grabbe S., “The role of alpha-metanocyte-stimulating hormone in cutaneous biology”, J.Investig.DermatoLSymp.Proc., 2: 87-93, 1997.
Rajora, N., Boccoli, G., Catania and Lipton J.M., “alpha-MSH Modulates Experimental Inflammatory Bowel Disease”, Peptides, 18: 381-385, 1997.
Romanos et al., “Foreign gene expression in yeast: a review”, 1992, Yeast 8:423-488.
Star, R.A.,Rajora N., Huang J., Stock R.C., Catania A. and Lipton J.M.; “Evidence of autocrine modulation of macrophage nitric oxide synthase by alph

Affiliated with

Also associated with

Rating

Melanocortin 1 receptor selective compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Melanocortin 1 receptor selective compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanocortin 1 receptor selective compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4163137