Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1995-03-14
1998-09-29
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
424 60, 435191, 43525235, 4352535, C12P 1714, A61K 744
Patent
active
058144951
ABSTRACT:
The present invention is directed to a process for producing melanins, their precursors and their analoges, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet weight per liter of growth medium. The enhanced production of melanin can be achieved by manipulating the constituents of the growth medium, and/or attenuating fermentations conditions, and/or by genetically engineering microorganisms to produce melanins, and/or mutating the microorganisms.
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Della-Cioppa et al., 1991, "Engineering of novel melanin pigments by expression of tyrosine genes in Escherichia coli," Enzyme and Microbial Technology 13 (6):522.
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Chedekal Miles R.
della-Cioppa Guy
Garger, Jr. Stephen J.
Grill Laurence K.
Sverlow Genadie G.
Biosource Technologies, Inc.
Halluin Albert P.
Hendricks Keith D.
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