Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-01-09
2007-01-09
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S575000
Reexamination Certificate
active
10339499
ABSTRACT:
Melanin concentrating hormone receptor ligands (especially substituted 2-(4-benzyl-piperazin-1-ylmethyl)-1H-benzoimidazole analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
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Eberle et al., Expression and Characterization of Melanin-concentrating Hormone Receptors on Mammalian Cell Lines, Peptides, (2004) vol. 25 pp. 1585-1595.
DeSimone Robert W.
Gustavson Linda M.
Hutchison Alan
Mach Christopher
Peterson John M.
Coleman Brenda
Fidel Seth A.
Kadlecek Ann T.
Neurogen Corporation
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