Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-25
2006-07-25
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S338000, C514S412000, C544S238000, C546S276700, C548S453000
Reexamination Certificate
active
07081458
ABSTRACT:
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
REFERENCES:
patent: 3845058 (1974-10-01), Lembo et al.
patent: 3865828 (1975-02-01), Korosi et al.
patent: 4139621 (1979-02-01), Gardner et al.
patent: 4370329 (1983-01-01), Scherm et al.
patent: 4370330 (1983-01-01), Scherm et al.
patent: 4374990 (1983-02-01), Weber et al.
patent: 4532240 (1985-07-01), Werbel et al.
patent: 4806536 (1989-02-01), Cross et al.
patent: 4868194 (1989-09-01), Carr et al.
patent: 4921863 (1990-05-01), Sugimoto et al.
patent: 4937246 (1990-06-01), Sugihara et al.
patent: 5179095 (1993-01-01), Oinuma et al.
patent: 5569659 (1996-10-01), Reitz et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: 5688798 (1997-11-01), Godel et al.
patent: 5753659 (1998-05-01), Mills et al.
patent: 5859246 (1999-01-01), Thurkauf et al.
patent: 5869488 (1999-02-01), Shue et al.
patent: 6048876 (2000-04-01), Annoura et al.
patent: 6057371 (2000-05-01), Glennon et al.
patent: 6127381 (2000-10-01), Basu et al.
patent: 6172229 (2001-01-01), Thurkauf et al.
patent: 6284761 (2001-09-01), Zhang et al.
patent: 6414149 (2002-07-01), Chu-Moyer et al.
patent: 6455528 (2002-09-01), Adachi et al.
patent: 6472394 (2002-10-01), McKittrick et al.
patent: 6541477 (2003-04-01), Goehring et al.
patent: 6638925 (2003-10-01), Czollner et al.
patent: 6664273 (2003-12-01), Burnett et al.
patent: 2001/0039286 (2001-11-01), Dinnell et al.
patent: 2001/0049367 (2001-12-01), Bennani et al.
patent: 620234 (1963-01-01), None
patent: 177392 (1986-04-01), None
patent: 211346 (1987-02-01), None
patent: 390654 (1990-10-01), None
patent: 624584 (1994-11-01), None
patent: 675118 (1995-10-01), None
patent: 1029851 (2000-08-01), None
patent: 1123928 (2001-08-01), None
patent: 549465 (1986-03-01), None
patent: 1378964 (1975-01-01), None
patent: P2001-226269 (2001-08-01), None
patent: 2002322163 (2002-11-01), None
patent: WO 93/16057 (1993-08-01), None
patent: WO 95/34540 (1995-12-01), None
patent: WO 96/22977 (1996-08-01), None
patent: WO 97/17961 (1997-05-01), None
patent: 97/40049 (1997-10-01), None
patent: WO 97/41108 (1997-11-01), None
patent: WO 97/44334 (1997-11-01), None
patent: WO 98/04528 (1998-02-01), None
patent: WO 98/11068 (1998-03-01), None
patent: WO 99/19301 (1999-04-01), None
patent: WO 99/54305 (1999-10-01), None
patent: WO 99/54320 (1999-10-01), None
patent: WO 00/23428 (2000-04-01), None
patent: WO 00/32582 (2000-06-01), None
patent: WO 00/51984 (2000-09-01), None
patent: WO 00/55139 (2000-09-01), None
patent: WO 00/68202 (2000-11-01), None
patent: WO 01/017965 (2001-03-01), None
patent: WO 01/21169 (2001-03-01), None
patent: WO 01/21577 (2001-03-01), None
patent: WO 01/82925 (2001-03-01), None
patent: WO 01/64676 (2001-09-01), None
patent: WO 01/87834 (2001-11-01), None
patent: WO 02/02744 (2002-01-01), None
patent: WO 02/04433 (2002-01-01), None
patent: WO 02/06245 (2002-01-01), None
Carpenter et al. Expert Opinion in Therapeutic Patents, vol. 12(11), p. 1639-1646 (2002).
Bednarek et al. Journal of Biological Chemistry, vol. 277, p. 13821-13826 (2002).
Lauteslager et al. Eur. J. Org. Chem. p.3105-3118 Aug. 2001.
Ziminayi et al. Medline Abstract for Curr.Pharm.Des. 9(8), p627-641 (2003).
Hervieu, Expert Opin.Ther.Targets 7(4), p. 495-511 (2003).
Hanano et al (2000) Bioorganic & Medicinal Chemistry Letters 10:881-84.
Boissier et al., J. Med. Chem. 6(5):541-544 (1963).
Petigara et al., (1968) J. Med. Chem. 11:332-336.
Doller Dario
Hutchison Alan J.
Peterson John M.
Pringle Wallace C.
Yin Helen
Bernhardt Emily
Fidel Seth A.
Kadlecek Ann T.
Neurogen Corp.
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