Melanin concentrating hormone receptor antagonist

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S254050, C544S364000, C544S366000

Reexamination Certificate

active

07659276

ABSTRACT:
Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula Iwherein A, W, X, Z, R1-R3, and R8are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.

REFERENCES:
patent: 6472394 (2002-10-01), McKittrick et al.
patent: 6552188 (2003-04-01), Kodama et al.
patent: 7078414 (2006-07-01), Kleemann et al.
patent: 7078430 (2006-07-01), Kumar et al.
patent: 7087638 (2006-08-01), Walter et al.
patent: 7091235 (2006-08-01), Friedman et al.
patent: 2002/0182655 (2002-12-01), Kostenis et al.
patent: 2003/0229119 (2003-12-01), Kym et al.
patent: 2 356 412 (2000-07-01), None
patent: 2 383 147 (2001-03-01), None
patent: 0 127 124 (1984-12-01), None
patent: 96/14307 (1996-05-01), None
patent: 98/03492 (1998-01-01), None
patent: 98/03493 (1998-01-01), None
patent: 98/03494 (1998-01-01), None
patent: 98/10068 (1998-03-01), None
patent: 00/39279 (2000-07-01), None
patent: 01/05947 (2001-01-01), None
patent: 01/21577 (2001-03-01), None
patent: 02/04433 (2002-01-01), None
patent: 02/094799 (2002-11-01), None
patent: 03/015769 (2003-02-01), None
patent: 03/045313 (2003-06-01), None
patent: 03/073999 (2003-09-01), None
patent: 03/087044 (2003-10-01), None
patent: 03/087046 (2003-10-01), None
Carpenter et al. Expert Opinion in Therapeutic Patents, vol. 12(11) p. 1639-1646 (2002).
Bednarek et al. Journal of Biological Chemistry, vol. 277, p. 13821-13826 (2002).
Dyke et al. Expert Opin.Ther.Patents, vol. 15, p. 1303-1313 (2005).
Banker, G. S., et al., Modern Pharmaceuticals, 1996, p. 596, Third Edition, Revised and Expanded.
Edwards, P. D., et al., “Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase,” Journal of Medicinal Chemistry, 1997, pp. 1876-1885, vol. 40, No. 12.
International Search Report, PCT/US04/25970, dated Mar. 3, 2005, 3 pages.
Lythgoe, D. J., Abstract of WO 1992/469592.
Marsh, D.J. et al., “Melanin-Concentratiing Hormone 1 Receptor-Deficient Mice Are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism”, PNAS, (2002), pp. 3240-3245, vol. 99:5.
Nabeya, A., et al., “Diaziridines. 2. Isomerization of N-Carbamoyldiaziridines,” Journal of Organic Chemistry, 1979, pp. 3935-3938, vol. 44, No. 22.
Stamos, I. K., “Aldehyde-Enamines from α-Oxocarboxylic Acids. A Facile and General Route to Aldehydes Via Decarboxylation of α-Oxocarboxylic Acids Carrying β-Hydrogens,” Tetrahedron Letters, 1982, pp. 459-462, vol. 23, No. 4.
Supplementary Partial European Search Report, PCT/US2004/025970, dated Oct. 31, 2007, 6 pages.
Walker, G. N., et al., “Synthesis of Varied Heterocyclic and Substituted Aryl Alkyl Secondary Amines, Related Schiff Bases, and Amides,” Journal of Medicinal Chemistry, Jul. 1966, pp. 624-630, vol. 9.
Weikert, R. J., et al., “Synthesis and Anthelmintic Activity of 3′-Benzoylurea Derivatives of 6-Phenyl-2,3,5,6-Tetrahydroimidazo[2,1-b]thiazole,” Journal of Medicinal Chemistry, 1991, pp. 1630-1633, vol. 34, No. 5.
Wissner, A., et al., “Analogues of Platelet Activating Factor. 7. Bis-Aryl Amide and Bis-Aryl Urea Receptor Antagonists of PAF,” Journal of Medicinal Chemistry, 1992, pp. 4779-4789, vol. 35, No. 26.
Wolff, M. E., Burger's Medicinal Chemistry and Drug Discovery, 1995, pp. 975-977, Fifth Edition, vol. 1: Principles and Practice.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Melanin concentrating hormone receptor antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Melanin concentrating hormone receptor antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanin concentrating hormone receptor antagonist will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4210298

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.